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To evaluate if continuous positive airway pressure(CPAP) on the lung undergoing lobectomy can decrease the inflammatory response PPC (postoperative pulmonary complications).

To evaluate if continuous positive airway pressure (CPAP) on the lung undergoing lobectomy can decrease the inflammatory response and PPC.

CPAP (Continuous airway pressure)

Lluis Gallart, PhD

This is a randomized placebo-controlled trial studying the effects of intraoperative continuous airway pressure (CPAP) on the inflammatory response of the lung with cancer undergoing lobectomy.

Pulmonary lobectomy induces an inflammatory response of this lung caused by intraoperative atelectasis and re-expansion. This inflammatory response can be attenuated with treatment, also decreasing postoperative pulmonary complications (PPC). Thus, avoiding complete atelectasis with partial insufflation of the lung during surgery could be useful to decrease inflammatory response and PPC.

Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation

Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response of the Lung With Cancer Undergoing Lobectomy. A Randomised Placebo-controlled Trial

Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.

Alveolar MICA I (major histocompatibility complex (MHC) class I chain related genes) expression measured at the same control times.

Postoperative distribution of well-aerated, non aerated or poorly aerated lung volumes.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation	NCT01368601	Lung Cancer	CPAP (Continuou...	18 Years - 80 Years	Parc de Salut Mar
Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation	NCT01368601	Lung Cancer	CPAP (Continuou...	18 Years - 80 Years	Parc de Salut Mar
Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation	NCT01368601	Lung Cancer	CPAP (Continuou...	18 Years - 80 Years	Parc de Salut Mar

Spots Global Cancer Trial Database for cpap (continuous airway pressure)