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Crystalloid based prime solution

Erythrocyte based prime solution

The primary aim of this study is to investigate the possibility to replace an erythrocyte based prime solution with a crystalloid based prime solution while maintaining metabolic function. Secondary also to study if potentially reduced immunological influence is obtained during hyper thermic isolated limb perfusion with a crystalloid based prime solution.

A Randomized Controlled Study Comparing Priming Solution Containing Crystalloid or Packed Red Blood Cells in Patients Treated With Isolated Limb Perfusion.

A Randomized Controlled Study With the Aim to Compare Crystalloid Prime Solution With a Prime Solution Containing Packed Red Blood Cells in Relation to the Patient's Regional Metabolic Needs and Immunological Influence During Isolated Limb Perfusion

Lactate level during and after perfusion.

Arterial oxygen and regional venous oxygen saturation during and after completion of perfusion.

Hematocrit during and after completion of perfusion.

Oxygen extraction during, and after perfusion.

Serious Adverse Events (SAEs) level III-V within 30 days.

Changes in proportion of immune cells measured as CD3 + (T cells), CD3 + 4 + (helper T cells), CD3 + 8 + (cytotoxic T cells), CD3 + DR + (activated T cells), CD3 + 4 + 45RA + (naive helper T cells), CD3 + 8 + 45RA + (naïve cytotoxic T cells), CD3 + 4 + 45RO + (helper T cells), CD3 + 8 + 45RO + (cytotoxic memory T cells), CD3-56 + 16 + (NK cells), CD3 + 56 + 16 + (activated T cells), CD5 + (T-cells and some B-cells), CD19 + (B cells), CD5 + 19 + (subset of mature B cells mainly form polyspecific antibodies of the IgM class) will be measured before ILP, after 7 and 30 days post ILP

Vastra Gotaland Region

Associate professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Randomized Controlled Study Comparing Priming Solution Containing Crystalloid or Packed Red Blood Cells in Patients Treated With Isolated Limb Perfusion.	NCT03073304	Melanoma Sarcoma	Crystalloid bas... Erythrocyte bas...	18 Years -	Vastra Gotaland Region
A Randomized Controlled Study Comparing Priming Solution Containing Crystalloid or Packed Red Blood Cells in Patients Treated With Isolated Limb Perfusion.	NCT03073304	Melanoma Sarcoma	Crystalloid bas... Erythrocyte bas...	18 Years -	Vastra Gotaland Region
A Randomized Controlled Study Comparing Priming Solution Containing Crystalloid or Packed Red Blood Cells in Patients Treated With Isolated Limb Perfusion.	NCT03073304	Melanoma Sarcoma	Crystalloid bas... Erythrocyte bas...	18 Years -	Vastra Gotaland Region

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