Symptoms and General Pathology

All Conditions

Nervous System Diseases

Wounds and Injuries

Pain

Spinal Cord Compression

Spinal Cord Diseases

Central Nervous System Diseases

Spinal Cord Injuries

Cumulative BED ≤ 100

Cumulative BED ≤ 130 Gy2

Pierre Thirion, Dr

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy may be effective in treating malignant spinal cord compression in patients who have received previous radiation therapy to the spine.

PURPOSE: This phase II trial is studying radiation therapy in treating patients with malignant spinal cord compression.

OBJECTIVES:

Primary

* To determine the efficacy of a biologically effective dose-based re-irradiation strategy, in terms of the response rate (based on the mobility score using the Tomita scale where improvement in mobility or stable mobility score will be regarded as a response) in patients with malignant spinal cord compression.

Secondary

* To determine quality of life as assessed by the EORTC QLQ-C15 PAL version 1.0 questionnaire.
* To determine the non-spinal radiation-induced toxicity using standard RTOG criteria.
* To determine the rate of long-term spinal toxicity and radiation-induced myelopathy using the RTOG SOMA morbidity grading system.

OUTLINE: Patients are divided into 2 groups according to the interval since their most recent radiotherapy to the involved area of the spinal cord.

* Group 1 (\< 6 months since prior radiotherapy): Patients undergo radiotherapy for a cumulative biologically effective dose (BED) ≤ 100 Gy_2 in addition to receiving other current treatment.
* Group 2 (≥ 6 months since prior radiotherapy): Patients undergo radiotherapy for a cumulative BED ≤ 130 Gy_2 in addition to receiving other current treatment.

Mobility score is assessed and patients complete a quality-of-life assessment at baseline and at each follow-up visit starting at week 5.

After completion of study treatment, patients are followed up at 1 and 5 weeks, at 3 months, and then every 3 months thereafter.

Spinal Cord Compression Re-Treat Study

A Phase II Trial Evaluating the Efficacy of a Radio-Biological Based Re-Irradiation Strategy for Patients With Malignant Spinal Cord Compression

Cancer Trials Ireland

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Spinal Cord Compression Re-Treat Study	NCT00974168	Pain Radiation Toxic... Spinal Cord Com... Unspecified Adu...	Cumulative BED ... Cumulative BED ...	18 Years - 120 Years	Cancer Trials Ireland
Spinal Cord Compression Re-Treat Study	NCT00974168	Pain Radiation Toxic... Spinal Cord Com... Unspecified Adu...	Cumulative BED ... Cumulative BED ...	18 Years - 120 Years	Cancer Trials Ireland

Spots Global Cancer Trial Database for cumulative bed ≤ 130 gy2