Symptoms and General Pathology

All Conditions

Neoplasms

Hyperplasia

Polyps

Adenomatous Polyps

Pathological Conditions, Anatomical

Adenoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Anti-Inflammatory Agents

Antineoplastic Agents

Antirheumatic Agents

Analgesics

All Drugs and Chemicals

Curcumin

placebo to be taken orally via capsule form in the dose of 4 grams daily for a duration of four months

Curcuminoids C3 Complex® or placebo to be taken orally via capsule form in the dose of 4 grams daily for a duration of four months

Curcuminoids

Carmen E Guerra, M.D.

Specific Aims:

* To determine if curcuminoids modulate cellular proliferation as measured by proliferating cell nuclear antigen (PCNA) in the colorectal mucosa of subjects with previously resected adenomatous colonic polyps.

Hypothesis: Curcuminoids decrease cellular proliferation in the colorectal mucosa of subjects with previously resected sporadic adenomatous colonic polyps.

* To determine if curcuminoids modulate apoptosis, as measured by TUNEL assay, in the colorectal mucosa of subjects with previously resected adenomatous colonic polyps.

Hypothesis: Curcuminoids increase apoptosis in colorectal mucosa of subjects with previously resected sporadic adenomatous colonic polyps.

* To determine if curcuminoids modulate COX-2 expression as measured by immunohistochemical assays in subjects with previously resected adenomatous colonic polyps

Hypothesis: Curcuminoids decrease colorectal mucosa COX-2 expression in subjects with previously resected sporadic adenomatous colonic polyps.

* To determine if curcuminoids modulate COX-2 activity as measured by urinary eicosanoids

Hypothesis: Curcuminoids decrease concentrations of urinary eicosanoids.

Curcumin for the Chemoprevention of Colorectal Cancer

Phase II Double Blind Placebo-Controlled Trial of Curcuminoids' Effect on Cellular Proliferation, Apoptosis and COX-2 Expression in the Colorectal Mucosa of Subjects With Recently Resected Sporadic Adenomatous Polyps

Robert Wood Johnson Foundation

University of Pennsylvania

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Curcumin for the Chemoprevention of Colorectal Cancer	NCT00118989	Adenomatous Pol...	Curcuminoids	18 Years -	University of Pennsylvania
Curcumin for the Chemoprevention of Colorectal Cancer	NCT00118989	Adenomatous Pol...	Curcuminoids	18 Years -	University of Pennsylvania

Spots Global Cancer Trial Database for curcuminoids

Every month we try and update this database with for curcuminoids cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.