Neoplasms

All Conditions

Rare Diseases

Cholangiocarcinoma

Adenocarcinoma

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Bile Duct Cancer

Spyglass + RFA

Cytobrush + RFA

Jianfeng Yang

With the development of endoscopic technology, endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of extrahepatic cholangiocarcinoma.In patients with extrahepatic cholangiocarcinoma, cytological brushing performed concurrently with ERCP had a lower pathologically positive rate and increased the times of ERCPs, increased the risk of postoperative complications at the same time.The present study aims to compare the efficacy and safety outcomes of Spyglass+RFA Versus Cytobrush+RFA for Extrahepatic Cholangiocarcinoma.

Endoscopic retrograde cholangiopancreatography (ERCP) has been used as the primary method for the diagnosis of biliary strictures and the treatment of extrahepatic cholangiocarcinoma. However, the accurate visual diagnosis of malignant biliary strictures and assessment of the extent of a lesion are not possible by ERCP, and treatment of extrahepatic cholangiocarcinoma by ERCP procedures is sometimes difficult. In patients with extrahepatic cholangiocarcinoma, cytological brushing performed concurrently with ERCP had a lower pathologically positive rate and increased the times of ERCPs, increased the risk of postoperative complications at the same time. Spyglass enables direct visualization of the biliary tract and the sampling of suspicious lesions, together with radiofrequency ablation.Endoscopic radiofrequency ablation (RFA) is an emerging technique for the palliation of inoperable malignant biliary strictures (MBSs). In a dozen published studies, this novel approach has shown better safety and feasibility, as well as improvement in overall survival (OS). The present study aims to compare the efficacy and safety outcomes of Spyglass+RFA Versus Cytobrush+RFA for Extrahepatic Cholangiocarcinoma.

Spyglass+RFA Versus Cytobrush+RFA for Extrahepatic Cholangiocarcinoma

Comparison of SpyGlass Guided RFA On The Same Stage Versus RFA After Cytobrush for Extrahepatic Cholangiocarcinoma

Incidence of Postoperative complications such as bleeding and infection

First People's Hospital of Hangzhou

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Spyglass+RFA Versus Cytobrush+RFA for Extrahepatic Cholangiocarcinoma	NCT05233293	Extrahepatic Ch... Malignant Bilia...	Spyglass + RFA Cytobrush + RFA	18 Years -	First People's Hospital of Hangzhou
Spyglass+RFA Versus Cytobrush+RFA for Extrahepatic Cholangiocarcinoma	NCT05233293	Extrahepatic Ch... Malignant Bilia...	Spyglass + RFA Cytobrush + RFA	18 Years -	First People's Hospital of Hangzhou

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