Neoplasms

Digestive System Diseases

All Conditions

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Hematinics

All Drugs and Chemicals

Liver Extracts

During liver surgery Definity contrast dye will be administered follwed by an ultrasound to better detect liver tumors

Definity® injections given both pre-ablation and post-ablation

Definity®

Robert Martin, MD

The primary purpose of this study is to demonstrate the safety and effectiveness of using an intra-operative ultrasound contrast agent(Definity®) for the identification of known liver tumors.

The primary objective of this study is to demonstrate the safety of the use of intra-operative ultrasound contrast (Definity®) administration. The secondary objective of this study is to demonstrate the improved image quality and conspicuity of known liver tumors using contrast enhancement.

Evaluation of Intra-operative Ultrasound Contrast Enhancement in the Evaluation of Liver Tumors

University of Louisville

Immune System Diseases

Rare Diseases

Glioblastoma

Hypersensitivity

Astrocytoma

Glioma

Neoplasms, Neuroepithelial

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Glandular and Epithelial

Neoplasms, Nerve Tissue

Neuroepithelioma

* Once enrolled, participants would be prepared for standard of care surgery.
* The sonobiopsy involves the standard procedure for a biopsy, but the biopsy needle is replaced with a customized ultrasound probe, a standard ultrasound contrast agent (microbubbles) is injected intravenously, and the probe is turned on for 3 minutes for the sonobiopsy. Then the planned surgery to remove the tumor will occur.
* An additional brief MRI scan will be obtained using the intraoperative MRI to define imaging changes (if any) that occur as a result of the sonobiopsy procedure. The imaging protocols will include a 3D T2-weighted (T2w) scan, and 3D contrast T1-weighted (T1w) with dynamic contrast enhancement and if time allows T2\* sequence.
* Blood will be collected at several time points.
* A small skin biopsy or another blood draw will be drawn for comparison against the genetic mutations shown in the tumor.
* The blood, tumor, and skin (if applicable) will undergo genetic analysis.

Ultrasound combined with microbubbles to facilitate sampling of biomarkers from brain tumors via blood-based liquid biopsy

Sonobiopsy

No more than 10 minutes prior to ultrasound sonication, 10 minutes after ultrasound sonication, 30 minutes after ultrasound sonication (optional at the discretion of the PI), and 60 minutes after ultrasound sonication (optional at the discretion of the PI)

Research blood

Cancer Personalized Profiling by deep Sequencing will be used to compare the frequency of tumor-specific variants in the blood before and after sonobiopsy.

Cancer Personalized Profiling

Albert Kim, M.D.

Eric Leuthardt, M.D.

Hong Chen, Ph.D.

This clinical study to evaluate sonobiopsy is significant because sonobiopsy will fundamentally enhance the clinician's insight into the molecular features of an intracranial lesion to tailor treatment approaches and optimize outcomes. In addition to the standard diagnostics of anatomic imaging and surgical histology, sonobiopsy has the potential to become the third pillar for brain tumor management by radically advancing the ability to easily and regularly acquire tumor genetic and molecular signatures. This enhanced capability will have a dramatic impact on patient survival and quality of life.

Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma

The feasibility of sonobiopsy will be demonstrated by an increase in the amount of ctDNA in the blood samples acquired post than prior sonobiopsy in at least 50% of the patients.

The agreement of the post-sonobiopsy sample mutation detected in the blood with a variant identified in the tumor tissue will be compared using a kappa statistic.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Evaluation of Intra-operative Ultrasound Contrast Enhancement in the Evaluation of Liver Tumors	NCT00955097	Liver Tumors	Definity®	18 Years -	University of Louisville
Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma	NCT05281731	Glioblastoma Glioblastoma Mu...	Sonobiopsy Research blood Cancer Personal... Definity®	18 Years -	Washington University School of Medicine

Spots Global Cancer Trial Database for definity®

Every month we try and update this database with for definity® cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for definity®

Every month we try and update this database with for definity® cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for definity® cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.