Neoplasms

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administration of 0.9% normal saline 10ml

administration of 0.5ug/kg of dexmedetomidine (5ml)

administration of 0.5 ug/kg of dexmedetomidine and dexamethasone 5mg (total 5ml)

administration of dexmedetomidine and dexamethasone

Dexmedetomidine and dexamethasone

Control

Previous reports demonstrated that dexmedetomidine could reduce the incidence of postoperative nausea and vomiting (PONV). Dexamethason also had been commonly used for ajuvant drugs for preventing and reducing PONV. So investigator want to study about the effect of dexmedetomidine only or combined with dexamethasone for preventing PONV.

Previous reports demonstrated that dexmedetomidine, a alpha 2 selective agonist could reduce the incidence of postoperative nausea and vomiting (PONV). Dexamethason also had been commonly used for ajuvant drugs for preventing and reducing PONV. So investigator want to study about the effect of dexmedetomidine only or combined with dexamethasone for preventing PONV.

Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer

Effects of Single Dose Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer

Numeric rating scale for postoperative nausea (scores on a scale) (0-no symptoms; 10-worst symptoms imaginable). Ramosetron 0.3 mg was administered to patients with nausea \>5 points on the numeric rating scale

frequencies of vomiting (number of participants with vomiting) 24 hour post-operatively

Rhodes Index of nausea, vomiting, and retching at 6 to 24 hours after surgery (ask 8 question about discomfort due to PONV and each questions are consist of 0\~4 score) (minimal PONV 0 to maximal PONV 32) lower values represent a bettwer outcome

Gachon University Gil Medical Center

Assistant professor

administration of 0.9% normal saline 10ml

Control: administration of normal saline

administration of 0.5ug/kg of dexmedetomidine (5ml)

Dexmedetomidine: administration of dexmedetomidine only

administration of 0.5 ug/kg of dexmedetomidine and dexamethasone 5mg (total 5ml)

Dexmedetomidine and dexamethasone: administration of dexmedetomidine and dexamethasone

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer	NCT02550795	Postoperative N...	Dexmedetomidine Dexmedetomidine... Control	20 Years - 65 Years	Gachon University Gil Medical Center
Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer	NCT02550795	Postoperative N...	Dexmedetomidine Dexmedetomidine... Control	20 Years - 65 Years	Gachon University Gil Medical Center

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