Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Carcinoma

Carcinoma, Squamous Cell

Adenocarcinoma

Uterine Cervical Neoplasms

Carcinoma, Adenosquamous

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Cervical Diseases

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

CT Abdomen and Pelvis + whole body PET-CT

CT Abdomen and Pelvis scan + whole body PET-CT scan

CT Abdomen and Pelvis scan

Laurie Elit, MD

Anthony Fyles, MD

Greg Pond, PhD

Mark Levine, MD

Karen Gulenchyn, MD

Mostafa Atri, MD

Douglas Coyle, PhD

The purpose of this trial is to improve the clinical management and outcome of patients with locally advanced cervical cancer by using positron emission tomography-computed tomography (PET-CT) imaging.

There is considerable debate worldwide regarding the utility of PET for staging cervical cancer. Although there are studies on the accuracy (sensitivity and specificity) of PET in cervical cancer, there are currently no prospective randomized studies on how PET information affects treatment decisions and outcomes.

Cervical cancer is the second most common cause of cancer deaths worldwide. In Canada, it is estimated that in 2009 there will be 1,300 new cases of cervical cancer and that 380 women will die of this disease. The corresponding 2009 data for Ontario is 500 new cases and 140 deaths. In Canada, cervical cancer screening with the Pap test allows for the diagnosis and curative treatment of precancerous lesions of the cervix or early cervical cancers. Symptoms of cervical cancer include vaginal bleeding and discharge. Unfortunately these are often associated with more advanced disease.

The costs associated with health care are increasing. PET is an expensive imaging modality. Given that resources for health care are not unlimited, there needs to be high quality evidence of an intervention such as PET's efficacy.

Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE Trial)

The Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer

Ontario Ministry of Health and Long Term Care

Ontario Clinical Oncology Group (OCOG)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE Trial)	NCT00895349	Cervical Cancer Squamous Cell C... Adenosquamous C... Adenocarcinoma	CT Abdomen and ... CT Abdomen and ...	18 Years -	Ontario Clinical Oncology Group (OCOG)
Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE Trial)	NCT00895349	Cervical Cancer Squamous Cell C... Adenosquamous C... Adenocarcinoma	CT Abdomen and ... CT Abdomen and ...	18 Years -	Ontario Clinical Oncology Group (OCOG)

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