Neoplasms

All Conditions

Nervous System Diseases

Symptoms and General Pathology

Digestive System Diseases

Carcinoma

Sarcopenia

Carcinoma, Hepatocellular

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Muscular Atrophy

Atrophy

Neuromuscular Manifestations

Neurologic Manifestations

Pathological Conditions, Anatomical

The chair stand test was administered, and the time required for the patient to stand five times from a sitting position without using the arms was measured. CT scan was to scan the patient's third lumbar level. For the gait speed test, the time that patients spent walking 8 meters on a flat indoor floor at usual walking speed was measured.Grip strength test:the dominant hand and the nondominant hand were measured twice intermittently (kg), and the average value of 4 values was obtained.

Diagnostic Test: gait speed; ct scan; grip strength and chair stand test

Sarcopenia is associated with the prognosis of HCC and cholangiocarcinoma. But there has been rare study focusing on the effect of sarcopenia on the prognosis of HCC treated with systemic therapy, such as interventional therapy, targeted therapy, chemotherapy and immunotherapy and so on.

By tracking the short-term and long-term results of HCC patients treated with systemic therapy,the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after systemic treatments was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.All implementation details are based on the newest EuropeanWorking Group on Sarcopenia in Older People(EWGSOP) definition. The investigators consecutively admitted patients the questionnaire and evaluated the assessment of muscle strength (grip strength test and chair stand test), muscle quantity (L3 plane total skeletal muscle area) and physical performance (gait test) following the F-A-C-S approach, to confirm patients with sarcopenia accurately. And by tracking the short-term and long-term outcomes, the differences were analyzed and the relationship between sarcopenia and prognosis of systemic treatments was explored.

Effect of Sarcopenia on Hepatocellular Carcinoma(HCC) After Systemic Therapies

Effect of Sarcopenia on the Efficacy and Prognosis of HCC Treated With Systemic Therapies

The complications were classified according to the Clavien-Dindo classification, such as hypertension, fever, abdominal pain and so on.

Overall survival was defined as the time from initiation of lenvatinib to death for any reason.

Progression free survival was defined as the time from initiation of lenvatinib to first progression or death.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Effect of Sarcopenia on Hepatocellular Carcinoma(HCC) After Systemic Therapies	NCT05448222	Hepatocellular ... Sarcopenia	Diagnostic Test...	18 Years - 80 Years	First Affiliated Hospital of Wenzhou Medical University
Effect of Sarcopenia on Hepatocellular Carcinoma(HCC) After Systemic Therapies	NCT05448222	Hepatocellular ... Sarcopenia	Diagnostic Test...	18 Years - 80 Years	First Affiliated Hospital of Wenzhou Medical University

Spots Global Cancer Trial Database for diagnostic test: gait speed; ct scan; grip strength and chair stand test