Respiratory Tract (Lung and Bronchial) Diseases

Symptoms and General Pathology

All Conditions

Neoplasms

Digestive System Diseases

Rare Diseases

Respiratory Aspiration

Esophageal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Head and Neck Neoplasms

Gastrointestinal Diseases

Esophageal Diseases

Respiration Disorders

Respiratory Tract Diseases

Esophageal Cancer

inspiratory muscle training will start with an intensity of 30% of maximal inspiratory pressure, 15 times/set, 3 sets/day, 7 days/week and training will continue until surgery is scheduled or 2 weeks after the completion of treatment if surgery is not suitable.

inspiratory muscle training

The purpose of this study is to investigate the effectiveness of inspiratory muscle training (IMT) on respiratory performance in patients with esophageal cancer during combined modality therapy.

Background and Purpose: Incidence rates of esophageal cancer remain high in Eastern Asia. In 2012, esophageal cancer was the 9th leading cause of cancer deaths in Taiwan. Whether surgical resection is possible, combined modality therapy is usually required for the treatment of esophageal cancer. In clinical observation, patients underwent combined modality therapy usually demonstrated respiratory muscle dysfunction which might further impair physical activity and quality of life. The purpose of this study is to investigate the effectiveness of inspiratory muscle training (IMT) on respiratory performance in patients with esophageal cancer during combined modality therapy.

Methods: This is a prospective interventional study design. A total of 45 patients with newly diagnosed esophageal cancer will be recruited from the Mackay Memorial Hospital. All tests will be performed at baseline (prior to cancer treatment), weekly during treatment, prior to surgery, and one month after surgery. Tests will include demographic data collection, respiratory muscle performance (maximal inspiratory and expiratory pressure tests combined with diaphragmatic surface electromyography, and pulmonary functional test), dyspnea, and the functional exercise test (6-min walk test). IMT will start with an intensity of 30% of maximal inspiratory pressure, 15 times/set, 3 sets/day, 7 days/week and training will continue until surgery is scheduled or 2 weeks after the completion of treatment if surgery is not suitable. Repeated measure ANOVA will be used for analyzing difference of parameters among various time points.

Clinical relevance: The results of this study will help to better understand the clinical beneficial effects (e.g., better functional capacity) of an added inspiratory muscle training during combined modality therapy in patients with esophageal cancer.

Efficacy of Inspiratory Muscle Training on Respiratory Performance in Patients With Esophageal Cancer Receiving Combined Modality Therapy

Change from baseline MIP at the end of each week's CCRT treatment

Change from baseline MEP at the end of each week's CCRT treatment

Change from baseline EMGdi at the end of each week's CCRT treatment

Change from baseline FEV1 at the end of each week's CCRT treatment

Change from baseline FVC at the end of each week's CCRT treatment

Change from baseline 6-minute walking distance at the end of each week's CCRT treatment

Change from baseline Modified Borg Dyspnea score at the end of each week's CCRT treatment

Mackay Memorial Hospital

VS. Division of Radiation Oncology, Department of Radiology

The purpose of this study is to investigate the effect of concurrent chemoradiation therapy on respiratory muscle performance, lung function and functional capacity in patients with local esophagus cancer.

This is a prospective observational study design. A total of 45 patients with newly diagnosed esophageal cancer will be recruited from the Mackay Memorial Hospital. All tests will be performed at baseline (prior to cancer treatment), weekly during treatment, prior to surgery, and one month after surgery. Tests will include demographic data collection, respiratory muscle performance (maximal inspiratory and expiratory pressure tests combined with diaphragmatic surface electromyography, and pulmonary functional test), dyspnea, and the functional exercise test (6-min walk test).Repeated measure ANOVA will be used for analyzing difference of parameters among various time points.

Effect of Concurrent Chemoradiation Therapy on Respiratory Muscle Performance, Lung Function and Functional Capacity in Patients With Local Esophagus Cancer

Change from baseline MIP at the end of each week's treatment, and 2 weeks after the completion of treatment

Change from baseline EMGdi at the end of each week's treatment, and 2 weeks after the completion of treatment

Change from baseline FEV1 at the end of each week's treatment, and 2 weeks after the completion of treatment

Change from baseline FVC at the end of each week's treatment, and 2 weeks after the completion of treatment

Change from baseline 6-minute walking distance at the end of each week's treatment, and 2 weeks after the completion of treatment

Change from baseline Modified Borg Dyspnea score at the end of each week's treatment, and 2 weeks after the completion of treatment

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Efficacy of Inspiratory Muscle Training on Respiratory Performance in Patients With Esophageal Cancer Receiving Combined Modality Therapy	NCT03099629	Esophageal Canc...	inspiratory mus...	20 Years -	Mackay Memorial Hospital
Effect of Concurrent Chemoradiation Therapy on Respiratory Muscle Performance, Lung Function and Functional Capacity in Patients With Local Esophagus Cancer	NCT03120572	Esophageal Canc...		20 Years -	Mackay Memorial Hospital
Effect of Concurrent Chemoradiation Therapy on Respiratory Muscle Performance, Lung Function and Functional Capacity in Patients With Local Esophagus Cancer	NCT03120572	Esophageal Canc...		20 Years -	Mackay Memorial Hospital
Effect of Concurrent Chemoradiation Therapy on Respiratory Muscle Performance, Lung Function and Functional Capacity in Patients With Local Esophagus Cancer	NCT03120572	Esophageal Canc...		20 Years -	Mackay Memorial Hospital
Efficacy of Inspiratory Muscle Training on Respiratory Performance in Patients With Esophageal Cancer Receiving Combined Modality Therapy	NCT03099629	Esophageal Canc...	inspiratory mus...	20 Years -	Mackay Memorial Hospital

Spots Global Cancer Trial Database for diaphragmatic surface electromyography