Nutritional and Metabolic Diseases

Gland and Hormone Related Diseases

All Conditions

Neoplasms

Digestive System Diseases

Rare Diseases

Diabetes Mellitus

Diabetes Mellitus, Type 2

Stomach Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Stomach Diseases

Stomach Cancer

Subtotal gastrectomy with BillrothⅠ or BillrothⅡ, total gastrectomy with jejunal interposition or Roux-en-Y reconstruction

digestive tract reconstruction

Zhao Yan, Doctor

Different digestive tract reconstruction will affect the blood glucose level of gastric cancer with type 2 diabetes. Subtotal gastrectomy with Billroth II reconstruction and total gastrectomy with Roux-en-Y reconstruction may help to improve glycaemic control which includes fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of gastric cancer patients with type 2 diabetes.

Different digestive tract reconstruction will affect the blood glucose level of gastric cancer with type 2 diabetes. Subtotal gastrectomy with Billroth II reconstruction and total gastrectomy with Roux-en-Y reconstruction may help to improve glycaemic control which includes fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of gastric cancer patients with type 2 diabetes.

The investigators will observed fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of the patients preoperation, 14 days postoperation 3 month and 6month postoperation. The investigators will observed the effect of blood glucose to different digestive tract reconstruction after gastrectomy of gastric cancer with type 2 diabetes

Digestive Tract Reconstruction After Gastrectomy of Gastric Cancer With Type 2 Diabetes

The Effect of Blood Glucose to Different Digestive Tract Reconstruction After Gastrectomy of Gastric Cancer With Type 2 Diabetes

Tianjin Medical University Cancer Institute and Hospital

Carcinoma

Pancreatic Neoplasms

Pancreatic Cancer

Gastrointestinal Agents

All Drugs and Chemicals

Pancrelipase

Pancreatin

Modified method of digestive tract reconstruction: Evaluate the resectability; Remove pancreas head, gastric pyloric antrum, duodenum, distal common bile duct and regional lymph nodes; Reconstruct digestive tract with an independent intestinal loop and pancreas end.

Routine digestive tract reconstruction: Evaluate the resectability; Remove pancreas head, gastric pyloric antrum, duodenum, distal common bile duct and regional lymph nodes;Reconstruct the common bile duct-jejunum and pancreatic duct-jejunum respectively.

Modified method of digestive tract reconstruction

Routine digestive tract reconstruction

Huai-zhi Wang, M.D., Ph.D.

Liang-yu Yin, M.D.

Huai-zhi Wang, M.D., Ph.D

The purpose of this study is to evaluate the validity and safety of a modified operative procedure of digestive tract reconstruction following pancreatoduodenectomy which enables the pancreatic juice and bile to bypass at the pancreatointestinal anastomosis and merge at gastrointestinal anastomosis. It is anticipated that this procedure can decrease the risk of post-surgical pancreatic leakage and preserve the patients' digestive function as well.

Pancreatoduodenectomy (PD) is one of the most complicated surgeries in abdominal clinical practice. It is widely used in the treatment of pancreatic head carcinoma, periampullary carcinoma, chronic pancreatitis with intractable pain, pancreatic head mass which unable to rule out pancreatic cancer. PD was improved in many ways in the last 80 years and the post-surgical mortality has decreased under 5%. Since the resected region of PD is wide including gall bladder, billiary tract, duodenum, pancreas, stomach, jejunum and regional lymph nodes. It has a high prevalence of complications, of which pancreatic leakage is the most common and serious one with a prevalence rate of 5-25% and mortality rate 20-50%。 The objective of the present study is to evaluate a new surgical procedure used for the digestive tract reconstruction following PD. The new procedure enables the pancreatic juice and bile to bypass at the pancreatointestinal anastomosis and merge at gastrointestinal anastomosis which can decrease the risk of post-surgical pancreatic leakage and keep the digestive function of patients. A multicenter, randomized, controlled study is designed to observe the prevalence of pancreatic leakage, other post-surgical complications, hospital stay, medical costs, life quality and other indexes to evaluate the efficacy and safety of this procedure. It is anticipated that through the study, this new procedure can be systematically verified if it is an ideal procedure of digestive reconstruction following PD which can be promoted into wider use.

Evaluation of A New Digestive Reconstruction Procedure Following Pancreatoduodenectomy

Evaluation of a Modified Procedure of Digestive Tract Reconstruction Following Pancreatoduodenectomy: A Multicenter Randomized Controlled Study

Southwest Hospital, China

Doctor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Digestive Tract Reconstruction After Gastrectomy of Gastric Cancer With Type 2 Diabetes	NCT01637350	Gastric Cancer	digestive tract...	18 Years - 75 Years	Tianjin Medical University Cancer Institute and Hospital
Evaluation of A New Digestive Reconstruction Procedure Following Pancreatoduodenectomy	NCT01931449	Pancreatic Canc... Periampullary C...	Modified method... Routine digesti...	18 Years - 80 Years	Southwest Hospital, China
Digestive Tract Reconstruction After Gastrectomy of Gastric Cancer With Type 2 Diabetes	NCT01637350	Gastric Cancer	digestive tract...	18 Years - 75 Years	Tianjin Medical University Cancer Institute and Hospital
Evaluation of A New Digestive Reconstruction Procedure Following Pancreatoduodenectomy	NCT01931449	Pancreatic Canc... Periampullary C...	Modified method... Routine digesti...	18 Years - 80 Years	Southwest Hospital, China

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