Neoplasms

Symptoms and General Pathology

All Conditions

Neoplasm Metastasis

Polyps

Intestinal Polyps

Neoplastic Processes

Pathological Conditions, Anatomical

Venous blood samples taken at the moment of colonoscopy to test for biomarkers

Blood test

Jean-François BOURGAUX

Anissa Megzari

The study authors hypothesize that in patients with intestinal polyps, tumor cells could disseminate and circulating factors could be secreted by the polyp. These two parameters could become biomarkers to refine the follow-up of patients and to establish targeted therapeutic strategies.

Venous blood collected at time of colonoscopy

Proof-of-concept Study of Blood Markers of Tumor Dissemination in Patients With Versus Without Intestinal Polyps

Number of disseminated circulating tumor cells found on the ANGLE Parsortix™ system

ng/mL, measured by Enzyme-Linked ImmunoSorbent Assay

Fecal immunochemical test positive / Personal history of colonic adenoma / Family history of colonic adenoma / Personal history of colorectal cancer / Family history of colorectal cancer / Rectal symptoms

Boston classification: ranked from 0 to 3 for each colonic segment explored

classed as complete colonoscopy after visualization of the caecal floor

Post-polypectomy bleeding / Perforation / Incomplete colonoscopy / No complications

Rectum / Sigmoid / Left Colon / Transverse Colon / Right Colon / Caecum

Paris classification: 0-Is / 0-Ip / 0-IIa / 0-IIb / 0-IIc / 0-III

Biopsy forceps / Cold loop / Diathermic loop / Mucosectomy / Unresected (Suspected Cancer, Unresectable in ambulatory)

Vienna classification: Nonspecific (Food Residue, Normal Mucosa or Colonic Fold) / Adenoma in Low Grade Dysplasia / Adenoma in High Grade Dysplasia / Cancer - Transformed Adenoma / Scalloped Adenoma / Hyperplastic Polyp.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Proof-of-concept Study of Blood Markers of Tumor Dissemination in Patients With Versus Without Intestinal Polyps	NCT05648240	Colorectal Canc... Neoplasm Metast... Disseminated Ca...	Blood test	18 Years -	Centre Hospitalier Universitaire de Nīmes
Proof-of-concept Study of Blood Markers of Tumor Dissemination in Patients With Versus Without Intestinal Polyps	NCT05648240	Colorectal Canc... Neoplasm Metast... Disseminated Ca...	Blood test	18 Years -	Centre Hospitalier Universitaire de Nīmes

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