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six cycles of neoadjuvant Docetaxel, Anthracycline and Cyclophosphamide

six cycles of neoadjuvant Docetaxel and Cyclophosphamide

Docetaxel 75mg/m2, doxorubicin 50mg/m2 or epirubicin 60mg/m2, cyclophosphamide 500mg/m2 every 3 weeks for six cycles

Docetaxel, Anthracycline (Doxorubicin or Epirubicin), Cyclophosphamide

Docetaxel 75mg/m2, cyclophosphamide 600mg/m2 every 3 weeks for six cycles

Docetaxel, cyclophosphamide

Kunwei Shen

The purpose of this study is to compare the pathological complete response (pCR) rate in triple-negative or Her2 positive breast cancer patients treated with neoadjuvant docetaxel, anthracycline and cyclophosphamide (TAC) or docetaxel and cyclophosphamide (TC) regimen.

Breast cancer is the leading cause of cancer in women in China. Neoadjuvant chemotherapy for treatment of locally advanced breast cancer has become a standard therapy. Results from neoadjuvant trials have shown that pathological complete response (pCR) is an independent predictor of outcome. Docetaxel was introduced into clinical practice in the early 1990s and has demonstrated good activity in the adjuvant and metastatic settings. Both TC and TAC are effective regimens in the adjuvant setting. The most optimal regimen in the neoadjuvant treatment is however unknown. This is especially true in triple-negative or HER2 positive breast cancer. This study will evaluate the pCR rate of TAC and TC as neoadjuvant treatment for triple-negative or HER2 positive breast cancer.

Neoadjuvant Treatment of Docetaxel, Anthracycline and Cyclophosphamide (TAC) Versus Docetaxel and Cyclophosphamide (TC) in Triple-Negative or Her2 Positive Breast Cancer

A Multi-Center, Randomized Study of Docetaxel, Anthracycline and Cyclophosphamide (TAC) Versus Docetaxel and Cyclophosphamide (TC) in Neoadjuvant Treatment of Triple-Negative or Her2 Positive Breast Cancer

Shanghai Jiao Tong University School of Medicine

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Neoadjuvant Treatment of Docetaxel, Anthracycline and Cyclophosphamide (TAC) Versus Docetaxel and Cyclophosphamide (TC) in Triple-Negative or Her2 Positive Breast Cancer	NCT00912444	Breast Cancer	Docetaxel, Anth... Docetaxel, cycl...	18 Years - 70 Years	Shanghai Jiao Tong University School of Medicine
Neoadjuvant Treatment of Docetaxel, Anthracycline and Cyclophosphamide (TAC) Versus Docetaxel and Cyclophosphamide (TC) in Triple-Negative or Her2 Positive Breast Cancer	NCT00912444	Breast Cancer	Docetaxel, Anth... Docetaxel, cycl...	18 Years - 70 Years	Shanghai Jiao Tong University School of Medicine

Spots Global Cancer Trial Database for docetaxel, anthracycline (doxorubicin or epirubicin), cyclophosphamide