Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Heart and Blood Diseases

Infections

Symptoms and General Pathology

Rare Diseases

Lung Neoplasms

Lung Diseases

Pulmonary Embolism

Embolism

Pneumonia

Constriction, Pathologic

Aortic Valve Stenosis

Respiratory Tract Diseases

Thrombosis

Embolism and Thrombosis

Vascular Diseases

Aortic Valve Disease

Heart Valve Diseases

Heart Diseases

Ventricular Outflow Obstruction

Imaging performed on scanner 1: Photon-Counting Detector CT

Imaging performed on scanner 2: Energy-Integrating Detector CT (128-slice)

Imaging performed on scanner 3: Energy-Integrating Detector CT (20-slice)

Patients will undergo imaging on a modern CT scanner with spectral imaging capabilities. A dose neutral spectral acquisition mode will routinely be used. Contrast material protocol and scan ranges are similar in all three arms.

Imaging on Scanner with Spectral Imaging Capabilities

Patients will undergo imaging on a modern 128-slice CT scanner (Siemens Healthineers) with energy-integrating detector and without spectral acquisition mode. Contrast material protocol and scan ranges are similar in all three arms.

CT Scan using an Energy-Integrating Detector CT (128 slice MDCT)

Patients will undergo imaging on a modern 20-slice CT scanner (Siemens Healthineers) with energy-integrating detector and without spectral acquisition mode. Contrast material protocol and scan ranges are similar in all three arms.

CT Scan using an Energy-Integrating Detector CT (20-slice MDCT)

Florian Schwarz, MD

CT scans of the chest / thorax are of great importance both in the initial diagnosis and in the follow-up of pulmonary or thoracic diseases. As an example, CT angiography of the pulmonary arteries (CTPA) is worldwide considered to be gold standard test in patients with a suspicion for pulmonary embolism.

The aim of this study is to measure and compare dose efficiency of modern CT scanners for unenhanced and contrast-enhanced scan protocols of the chest/thorax. Patients who are referred for a CT of the chest/thorax will be randomly assigned to one of the three CT scanners currently in use at our institution.

Randomization of patients referred for a CT scan of the thorax on one of three CT scanners routinely used for this purpose in our department

On Dose Efficiency of Modern CT-scanners in Chest Scans

On Dose Efficiency of Modern CT-scanners in Chest Scans- a Prospective, Randomized Study

We plan to share individual participant data upon request (pending final approval by the data protection officer).

Measured as signal, image noise and modulation transfer function equivalent parameters

measured as x-ray tube parameters such as dose length product (DLP)

measured by blinded evaluation by radiologists

University Hospital Augsburg

Neoplasm Metastasis

Neoplastic Processes

Patients will undergo imaging on scanner 1.

Patients will undergo imaging on scanner 2.

Patients will undergo imaging on scanner 3.

Patients will undergo imaging on a modern CT scanner with spectral imaging capabilities. A dose neutral spectral acquisition mode will routinely be used. Contrast material protocol and scan ranges are similar among all three arms.

Scan at CT scanner 1

Patients will undergo imaging on a modern 128 slice CT-scanner without spectral imaging capabilities. A standard acquisition protocol will be used. Contrast material protocol and scan ranges are similar among all three arms.

Scan at CT scanner 2

Patients will undergo imaging on a modern 20 slice CT-scanner without spectral imaging capabilities. A standard acquisition protocol will be used. Contrast material protocol and scan ranges are similar among all three arms.

Scan at CT scanner 3

CT-Staging is crucial for therapy planning of patients with malignancies. Dose efficiency and image quality are important parameters for these examinations. Up to now, scientific evidence of dose efficiency of modern CT scanners is mostly derived from retrospective analyses. This prospective study systematically analyzes dose efficiency and image quality of three modern CT scanners by randomization of patients who are scheduled for a CT scan to examine the status of malignancies. After giving informed consent and randomization (1:1:1), the CT scan will be performed at one of the modern CT scanners available at our department. This will allow a systematic allocation to the different scanners.

Randomization of patients referred for a staging CT scan one of three CT scanners routinely used for this purpose in our department

Dose Efficiency of Modern CT Scanners in Oncologic Scans

On Dose Efficiency of Modern CT-Scanners in the Staging of Malignancies - a Prospective Randomized Study

measured as signal, noise and modulation transfer function equivalent parameters derived from patient scans

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
On Dose Efficiency of Modern CT-scanners in Chest Scans	NCT04996693	Pneumonia Lung Cancer Pulmonary Embol... Pulmonary Disea... Aortic Stenosis	Imaging on Scan... CT Scan using a... CT Scan using a...	18 Years -	University Hospital Augsburg
Dose Efficiency of Modern CT Scanners in Oncologic Scans	NCT04989192	Neoplasms Neoplasm Metast... Metastatic Canc...	Scan at CT scan... Scan at CT scan... Scan at CT scan...	18 Years -	University Hospital Augsburg
Dose Efficiency of Modern CT Scanners in Oncologic Scans	NCT04989192	Neoplasms Neoplasm Metast... Metastatic Canc...	Scan at CT scan... Scan at CT scan... Scan at CT scan...	18 Years -	University Hospital Augsburg

Spots Global Cancer Trial Database for dose efficiency