Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Symptoms and General Pathology

Lung Neoplasms

Dyspnea

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Respiration Disorders

Signs and Symptoms, Respiratory

Patients will receive any usual care for their dyspnea as deemed appropriate by their clinicians.

Dyspnea intervention will be administered over two sessions

Patients will receive:

* Psychoeducation
* Relaxation training for reducing physiological stress
* Behavioral techniques for managing acute breathlessness

Dyspnea Intervention

Patients will receive any usual care for their dyspnea as deemed appropriate by their clinicians

Usual Care

Joseph Greer, PhD

This research study is evaluating a behavioral intervention designed to help people with advanced lung cancer manage dyspnea (i.e., breathlessness or shortness-of-breath).

Many individuals with advanced lung cancer experience debilitating breathlessness at some point during the course of their illness. Unfortunately, few interventions exist to treat this distressing symptom of cancer.

The purpose of this study is to test the efficacy of a brief behavioral intervention may help relieve breathlessness in individuals with advanced lung cancer. Participants will have a 50/50 chance of receiving the behavioral intervention or standard care. The principal investigator of the study, Dr. Joseph Greer, is a licensed clinical psychologist who has trained oncology nurses in how to deliver the behavioral intervention. The oncology nurses will meet with participants during their outpatient oncology appointments, such as chemotherapy infusions, to review the behavioral skills that may help with breathlessness. This intervention involves no medications but rather teaches patients skills for breathing control and relaxation of the body.

Research staff collecting patient-reported measures will be blind to study assignment group

Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer

Compare changes in the MMRCDS scores between study groups over the 24-week study period

Compare changes in the CDS scores between study groups over the 24-week study period

Compare changes in the FACT-L scores between study groups over the 24-week study period

Compare changes in anxiety and depression symptoms between study groups over the 24-week study period

Compare changes in self-reported leisure time physical activity score between study groups over the 24-week study period

Examine the degree to which intervention effects on patient reported outcomes are mediated by improved mastery in managing breathlessness (as measured by the Chronic Respiratory Disease Questionnaire)

Examine whether differences in reported dyspnea are moderated by patient demographic and clinical factors

Examine differences between study groups in rates of emergency department and hospitalizations

Compare the change between study groups in MMRCDS severity score from baseline to 8 weeks

Compare the change between study groups in the CDS score from baseline to 8 weeks

Compare the change between study groups in FACT-L from baseline to 8 weeks

Compare the change between study groups in anxiety and depression symptoms from baseline to 8 weeks

Compare the change between study groups in self-reported leisure time physical activity score from baseline to 8 weeks

Compare the change between study groups in the percentage of time spend immobile but awake on actigraphy

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer	NCT03089125	Lung Cancer	Dyspnea Interve... Usual Care	18 Years -	Massachusetts General Hospital
Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer	NCT03089125	Lung Cancer	Dyspnea Interve... Usual Care	18 Years -	Massachusetts General Hospital

Spots Global Cancer Trial Database for dyspnea intervention