Neoplasms

Digestive System Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Stomach Neoplasms

Ulcer

Polyps

Gastritis

Stomach Diseases

Stomach Ulcer

Gastrointestinal Diseases

Gastroenteritis

Peptic Ulcer

Duodenal Diseases

Intestinal Diseases

Stomach Cancer

Chronic Graft Versus Host Disease

patients were assigned to swallow MCE first, followed by the gastroscopy

Standard gastroscopy

Zhaoshen Li, Prof.

A new Magnetic-controlled Capsule Endoscopy (MCE) was developed by ANKON and got SFDA's approval in China in 2013. It has recently been evaluated to compare the diagnostic accuracy of MCE with that of standard gastroscopy for gastric diseases in 70 patients with encouraging results (In Press). To further testify the diagnostic accuracy of MCE for both the diffuse and focal diseases in stomach, we performed this single-blinded multi-center prospective study compared MCE with gastroscopy in patients with gastric symptoms and indication for upper GI Endoscopy.

Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases

Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases: A Prospective Self-controlled Comparative Multicenter Trial

RenJi Hospital

Nanfang Hospital, Southern Medical University

Chinese PLA General Hospital

General Hospital of Beijing PLA Military Region

Wuhan Union Hospital, China

Shandong Provincial Hospital

Peking Union Medical College Hospital

Changhai Hospital

Director of Gastroenterology Dept.

Gastrointestinal Neoplasms

Digestive System Neoplasms

Conventional ESD: Conventional ESD technique using IT2-Knife, Dual-Knife, Hook-Knife (Olympus Europe, Hamburg, Germany) ERBE VIO 300D (V2.1.4) RF-surgery system (ERBE Elektromedizin GmbH, Tübingen, Germany) Injection of fluid: Syringe

Group 2: Water-jet assisted HybridKnife® ESD technique using HybridKnife® (Erbe Elektromedizin GmbH, Tübingen, Germany) ERBE VIO 300D (V2.1.4) RF-surgery system (ERBE Elektromedizin GmbH, Tübingen, Germany)

Injection of fluid: Integrated in HybridKnife® with ERBEJet 2 water-jet surgery system (ERBE Elektromedizin GmbH, Tübingen, Germany)

Conventional ESD: Conventional ESD technique using IT2-Knife, Dual-Knife, Hook-Knife (Olympus Europe, Hamburg, Germany; Olympus Japan) ERBE VIO 300D (V2.1.4) RF-surgery system (ERBE Elektromedizin GmbH, Tübingen, Germany) Injection of fluid: Syringe

Conventional ESD

Group 2: Water-jet assisted HybridKnife® ESD technique using HybridKnife® (Erbe Elektromedizin GmbH, Tübingen, Germany) ERBE VIO 300D (V2.1.4) RF-surgery system (ERBE Elektromedizin GmbH, Tübingen, Germany) Injection of fluid: Integrated in HybridKnife® with ERBEJet 2 water-jet surgery system (ERBE Elektromedizin GmbH, Tübingen, Germany)

Hybridknife ESD

Horst Neuhaus

Pinghong Zhou

1. Introduction The aim of the study is to evaluate the efficacy and safety of ESD by use of a new water-jet assisted ESD system using the HybridKnife® in patients with early gastric neoplastic lesions in comparison to the conventional ESD established in Japan. The water-assisted ESD technology allows pressure controlled injection of fluids through the tip of a recently developed HybridKnife®. Submucosal injection, circumferential cutting and dissection of lesions as well as coagulation of bleeding can be performed with the same device without need for changing the instrument. These options should accelerate the procedure and may increase its safety and efficacy.
2. Hypothesis The water-jet assisted ESD technique using the HybridKnife® bears the advantage of less instrument changes due to the combination of high-frequency cutting and water-jet application in one single instrument. This should lead to a simplified ESD procedure, shorter learn-ing curve and especially to a shorter procedure time.

The water-jet assisted ESD technique should be shorter than the conventional ESD techniques using IT2-, Dual- and Hook-Knifes at least with the same safety and effectiveness.

Water-jet Assisted ESD vs Conventional ESD Technique for Treating Early Gastric Cancer

Water-jet Assisted Endoscopic Submucosal Dissection (ESD) in Comparison to Conventional ESD Technique for Treatment of Early Gastric Cancer

The primary objective of the study is the procedure time of ESD using the conventional ESD technique in comparison to the water-jet assisted HybridKnife®-ESD technique.

Resection of the targeted lesion including coagulation markers in one piece.

En-bloc resection and histological confirmation of horizontal and vertical free margins of neoplasia.

Tumor infiltrated (R1) or undetermined (RX) margins of the resected specimen.

procedure related morbidity and mortality

any complication occurs after procedure within 30 days, such as bleeding or perforation rates

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases	NCT02219529	Gastric Disease... Gastric Ulcer, Gastric Polyps, Early Gastric C... Chronic Gastrit...	MCE Standard gastro...	18 Years - 70 Years	Changhai Hospital
Water-jet Assisted ESD vs Conventional ESD Technique for Treating Early Gastric Cancer	NCT01943253	Stomach Neoplas...	Conventional ES... Hybridknife ESD	18 Years -	Shanghai Zhongshan Hospital
Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases	NCT02219529	Gastric Disease... Gastric Ulcer, Gastric Polyps, Early Gastric C... Chronic Gastrit...	MCE Standard gastro...	18 Years - 70 Years	Changhai Hospital

Spots Global Cancer Trial Database for early gastric cancer,