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Patients undergo B-mode ultrasound imaging of the liver over 15 minutes.

Ultrasound Tomography

Aya Kamaya

This pilot trial studies how well B-mode ultrasound imaging works in detecting liver cancer that is early in its growth and may not have spread to other parts of the body. Diagnostic procedures, such as B-mode ultrasound imaging, may help find and diagnose liver cancer and find out how far the disease has spread.

PRIMARY OBJECTIVES:

I. To investigate the use of quantitative ultrasound spectroscopy to detect early hepatocellular carcinoma (HCC) as an inexpensive and widely available quantitative (i.e. robust) method to confirm disease in developing countries.

OUTLINE:

Patients undergo B-mode ultrasound imaging of the liver over 15 minutes.

B-mode Ultrasound Imaging in Detecting Early Liver Cancer

Quantitative Ultrasound Spectroscopy to Early HCC

The Mid-band fit is related to the intensity of the returned ultrasound signal at different frequencies has been shown to change with tissue morphology.

Spectral intercept (SI) is mostly related to the number scatterers and their density in the tissue. Changes in the SI have been demonstrated to occur due to different pathologies and result from treatments that change the structure of the tissue being imaged.

Summarized as the maximum and/or average value over the lesion of interest (using a region of interest selection) and the liver image as a whole.

Stanford University

Professor of Radiology

334 patients with confirmed or suspected eHCC as indicated by EOB-MRI were to be included in this study in a population with high or extremely high-risk of hepatocellular carcinoma in chronic liver disease. Then Microwave ablation (MWA) was performed under EOB-MRI guidance in patients with confirmed or suspected eHCC.

Microwave ablation (MWA) was performed under EOB-MRI guidance in patients with confirmed or suspected eHCC.

HCC is one of most common causes of cancer-related death in the world due to lately diagnosis by typical hallmarks which rely on completed arterialization. So it is important to earlier diagnose and treat hypovascular early HCC(eHCC). The aim of this study is to evaluate the efficacy and safety of microwave ablation for early HCC, also to explore the feasibility of EOB-MRI (Gd-EOB-DTPA enhanced MRI) guided ablation.

The Efficacy and Safety of EOB-MRI Guided Microwave Ablation for Early HCC: A Multicenter, Prospective, Observational Study

Analyze the efficacy and safety of EOB-MRI-guided microwave ablation in the treatment of eHCC;

Ablation effect assessed by EOB-MRI one month after ablation

Shandong Provincial Hospital

Director of imaging magnetic resonance interventional diagnosis and Treatment Department, Shandong Provincial Hospital

Neoplasm Micrometastasis

A total of 110 patients with early HCC with nodular diameters of less than 3 cm and up to three nodules were randomly divided into LH (n=55) and RFA groups (n=55). Outcomes were carefully monitored and evaluated during the 3-year follow-up period

Laparoscopic Hepatectomy

Radiofrequency Ablation

Jian Chen

The purpose of this research is to compare short-term and long-term efficacy of laparoscopic hepatectomy and radiofrequency ablation in the Treatment of early hepatocellular carcinoma, and provide the evidence for the choice of surgical method from the pathology and cytology.

Background:The aim of this study was to compare the efficacy of laparoscopic hepatectomy(LH) with radiofrequency ablation (RFA) in the treatment of early hepatocellular carcinoma (HCC).

Methods:A total of 110 patients with early HCC with nodular diameters of less than 3 cm and up to three nodules were randomly divided into LH (n=55) and RFA groups (n=55). Outcomes were carefully monitored and evaluated during the 3-year follow-up period.

Results:

operation time, intraoperative blood loss, rate of blood transfusion, complications and mortality, postoperative liver function, resection margin, number of micrometastases ,long-term curative effect and survival time were collected and analysed.

groups t-test ，univariate/multivariate analysis, logistic regression analysis, mixed linear regression, Cox survival analysis ，Kaplan-Meier survival analysis，Log-rank survival curves were used.

Participants and researchers do not understand the test grouping, but the research designer arranges and controls all trials.

Laparoscopic Hepatectomy and Radiofrequency Ablation in the Treatment of Early Hepatocellular Carcinoma

A Randomized Controlled Trial of Laparoscopic Hepatectomy and Radiofrequency Ablation in the Treatment of Early Hepatocellular Carcinoma

follow-up after the surgery every 2 months, to understand relapse, death, statistics 1 year, 2-year and 3-year survival, disease-free survival, recurrence rate.

hepatic failure,hemorrhage,biliary leakage,ascites,intra-abdominal infection,pleural effusion,pulmonary infection,cardiac insufficiency.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
B-mode Ultrasound Imaging in Detecting Early Liver Cancer	NCT02774161	Cirrhosis Early Hepatocel... Fibrosis Stage I Hepatoc... Stage II Hepato...	Ultrasound Tomo...	18 Years -	Stanford University
The Efficacy and Safety of EOB-MRI Guided Microwave Ablation for Early HCC: A Multicenter, Prospective, Observational Study	NCT06096896	Early Hepatocel...	MWA	18 Years -	Shandong Provincial Hospital
Laparoscopic Hepatectomy and Radiofrequency Ablation in the Treatment of Early Hepatocellular Carcinoma	NCT02243384	Hepatocellular ...	Laparoscopic He... Radiofrequency ...	18 Years - 70 Years	Southwest Hospital, China
B-mode Ultrasound Imaging in Detecting Early Liver Cancer	NCT02774161	Cirrhosis Early Hepatocel... Fibrosis Stage I Hepatoc... Stage II Hepato...	Ultrasound Tomo...	18 Years -	Stanford University
The Efficacy and Safety of EOB-MRI Guided Microwave Ablation for Early HCC: A Multicenter, Prospective, Observational Study	NCT06096896	Early Hepatocel...	MWA	18 Years -	Shandong Provincial Hospital

Spots Global Cancer Trial Database for early hepatocellular carcinoma