Neoplasms

All Conditions

Infections

Symptoms and General Pathology

Rare Diseases

Cholangiocarcinoma

Opisthorchiasis

Adenocarcinoma

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Communicable Diseases

Trematode Infections

Helminthiasis

Parasitic Diseases

Bile Duct Cancer

Participants in this arm will not be given the eCHEC program

Participants in this arm will be given the eCHEC program as their intervention

The eCHEC program is the enhanced Community-based Health Education and Communication (CHEC) model to prevent O. viverrini in an effort to decrease cholangiocarcinoma (CCA) in Khon Kaen, Thailand

eCHEC program

Ricardo Angeles, MD, MPH, MHPEd, PhD

Gina Agarwal, MBBS, PhD

Pattapong Kessomboon, MD, PhD

Liver cancer, specifically cholangiocarcinoma (CCA), is very common in different areas in Thailand. Many factors make this cancer more common, such as liver fluke infection, older age, eating raw fish, family history of cancer, alcohol intake, taking certain medicines (praziquantel), low intake of fresh vegetable, and low education. In 2015, researchers from Khon Kaen University developed the Community-based Health Education and Communication (CHEC) program to prevent liver cancer caused by liver flukes in communities of the Khon Kaen province, Thailand.

The main aim of this 5-year research study is to enhance the CHEC program to prevent liver cancer, and test if it is effective in improving the knowledge and behaviours of community residents regarding how to prevent liver cancer. This study will take place in Khon Kaen, Thailand. Other aims are to:

1. Increase understanding in the community that make it difficult to prevent liver cancer, as well as community characteristics that can help prevent liver cancer;
2. Incorporate the program we develop in healthcare to prevent liver cancer in Thailand.

Evaluating a Community-Based Behaviour Change Communication Model to Prevent Cholangiocarcinoma in Khon Kaen, Thailand

Mean difference in the self-reported frequency of intake of raw fish in the intervention group compared to the control group. Self reported, pre- and post- intervention.

Mean difference in the self-reported frequency of intake of fruits and vegetables in the intervention group compared to the control group. Self reported, pre- and post- intervention.

Difference in the proportion of smoking habits in the intervention group compared to the control group. Self reported, pre- and post- intervention.

Mean difference in the intake of alcoholic beverages in the intervention group compared to the control group. Self reported, pre- and post- intervention.

Difference in the proportion of use of the medication praziquantel (prescribed or self-medicated) in the intervention group compared to the control group. Self reported, pre- and post- intervention.

Difference in the proportion of positive stool test of concentration of O. viverrini, pre- and post-intervention.

Difference in the mean concentration of O. viverrini in the stool test, pre- and post-intervention.

Mean difference in the stages of change for risk behaviours in the intervention group compared to the control group. Self reported, pre- and post- intervention.

Mean difference in knowledge score about in knowledge of preventative measures against CCA in the intervention group compared to the control group. Measured in questions included in the community survey.

Cardiobolic measure linked to developing cancer. Change in the mean body mass index calculated from height and weight (self-reported).

Cardiobolic measure linked to developing cancer. Change in the mean waist circumference (measured with measuring tape)

Cardiobolic measure linked to developing cancer. Change in the mean measured blood pressure (automated, validated device)

Mean difference in health literacy knowledge score in the intervention group compared to the control group. Self reported, pre- and post- intervention

Mean difference in quality of life in the intervention group compared to the control group. Self reported, pre- and post- intervention. Using the EuroQol-5 dimension-5 level (EQ-5D-5L) tool

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Evaluating a Community-Based Behaviour Change Communication Model to Prevent Cholangiocarcinoma in Khon Kaen, Thailand	NCT05321992	Cholangiocarcin... Liver Fluke-Rel... Opisthorchiasis	eCHEC program	20 Years -	McMaster University
Evaluating a Community-Based Behaviour Change Communication Model to Prevent Cholangiocarcinoma in Khon Kaen, Thailand	NCT05321992	Cholangiocarcin... Liver Fluke-Rel... Opisthorchiasis	eCHEC program	20 Years -	McMaster University

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