Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Behaviors and Mental Disorders

Symptoms and General Pathology

Urinary Bladder Neoplasms

Alcohol Drinking

Postoperative Complications

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urinary Bladder Diseases

Urologic Diseases

Male Urogenital Diseases

Drinking Behavior

All Drugs and Chemicals

Anti-Infective Agents

Central Nervous System Depressants

Tin Fluorides

Ethanol

Standard treatment is information about benefits of stopping drinking and smoking before surgery and if wanted, advice about who to contact to get support.

5 meetings within 6 weeks containing education and pharmacologic support

Educational programme for smoking and alcohol cessation

Hanne Tønnesen, Professor

Radical cystectomy provides the best cancer-specific survival for muscle-invasive urothelial cancer. However the postoperative morbidity remains at 11-68 %. Smoking and alcohol consumption above two drinks per day is associated with an increased risk of postoperative morbidity. Six-eight weeks of smoking and alcohol abstinence prior to elective surgery is recommended to reduce this risk, but for cancer patients the preoperative period is often very short. This randomised clinical trial (STOP-OP) will reach a conclusion on the effect of a new Gold Standard Programme for both smoking and alcohol cessation Intervention using the Gold Standard Programme (GSP) on the frequency and severity of postoperative complications after bladder cancer surgery.

The study is a multicentre randomised clinical trial involving 110 patients with a risky alcohol intake (exceeding 21 alcohol units (252 g ethanol) per week or/ and daily smoking scheduled for bladder cancer surgery. Patients will be randomised to the 6-weeks GSP or treatment as usual (control). The GSP combines patient education and pharmacologic strategies. The GSP includes benzodiazepine therapy for withdrawal symptoms, controlled disulfiram therapy, and Nicotine replacement.

Intensive Smoking and Alcohol Cessation Intervention in Bladder Cancer Surgery Patients

Randomised Controlled Multicenter Study.Effect of an Intensive Smoking- and/or Alcohol Cessation Intervention Placed Shortly Before and 5 Weeks After Bladder Cancer Surgery on Postoperative Complications

Both number of patients with postoperative complications and number of postoperative complications according to the Clavien Dindo classification will be measured

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Intensive Smoking and Alcohol Cessation Intervention in Bladder Cancer Surgery Patients	NCT02188446	Bladder Cancer Smoking Alcohol Consump...	Educational pro...	18 Years - 100 Years	Rigshospitalet, Denmark
Intensive Smoking and Alcohol Cessation Intervention in Bladder Cancer Surgery Patients	NCT02188446	Bladder Cancer Smoking Alcohol Consump...	Educational pro...	18 Years - 100 Years	Rigshospitalet, Denmark
Intensive Smoking and Alcohol Cessation Intervention in Bladder Cancer Surgery Patients	NCT02188446	Bladder Cancer Smoking Alcohol Consump...	Educational pro...	18 Years - 100 Years	Rigshospitalet, Denmark

Spots Global Cancer Trial Database for educational programme for smoking and alcohol cessation