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Subjects in the arm are asked to do the effortful swallowing exercise at home for 8 weeks. The training frequency is to exercise 3-4 days/week, 3 times/day, 10 repetitions per time. Besides the at home exercise, each subject is scheduled to meet the investigator at the hospital at weekly basis to discuss and review his/her exercise practice.

Subjects in the arm are asked to do the Mendelsohn swallowing exercise at home for 8 weeks. The training frequency is to exercise 3-4 days/week, 3 times/day, 10 repetitions per time. Besides the at home exercise, each subject is scheduled to meet the investigator at the hospital at weekly basis to discuss and review his/her exercise practice.

voluntarily increases the posterior tongue base pushing effort while swallowing

effortful swallowing exercise

voluntarily increase the extent and duration of laryngeal elevation while swallowing

Mendelsohn swallowing exercise

Jenq-Yuh Ko, M.D., Ph.D.

This study is designed to investigate the treatment efficacy of 8 weeks swallowing exercise programs for patients with NPC after radiation therapy. This study also compares two different swallowing exercise: effortful swallow and Mendelsohn's maneuver, to see which one can bring more benefits to patients after a certain period of exercise training. Three assessment tools are selected to evaluate the study result: Mann Assessment of Swallowing Ability (MASA), videofluoroscopic swallowing study (VFSS), and Chinese version Swallowing Quality-of-Life Questionnaire (CSWAL-QOL). The hypothesis of this study is that the effortful swallowing exercise would have better treatment efficacy.

Swallowing Exercises for Nasopharyngeal Cancer After Radiation Therapy

Swallowing Exercises for Patients With Nasopharyngeal Cancer After Radiation Therapy

The the Mann Assessment of Swallowing Ability (MASA) is designed to yield specific information about a patients's swallowing ability through examiner interpretation of responses. Two scores are obtained: a total score out of 200, and an ordinal risk rating for both aspiration and dysphagia (definite, probable, possible, unlikely).

Videofluoroscopic swallowing study (VFSS) measures the bolus transit time including: 1.oral transit time; 2. pharyngeal transit time; and 3. pharyngeal delay time. It also reveals the occurrence of swallowing aspiration or not.

The Chinese version of SWAL-QOL questionnaire (CSWAL-QOL) contains 10 scales related to swallowing and quality of life, including burden, eating desire, food duration, food selection, communication, fear, mental health, social functioning, sleep, and fatigue. All scales are linearly transformed into a 0-to-100 metric, with 0 indicating most dysfunction and 100 indicating no dysfunction.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Swallowing Exercises for Nasopharyngeal Cancer After Radiation Therapy	NCT01937793	Nasopharyngeal ... Dysphagia	effortful swall... Mendelsohn swal...	20 Years - 70 Years	National Taiwan University Hospital
Swallowing Exercises for Nasopharyngeal Cancer After Radiation Therapy	NCT01937793	Nasopharyngeal ... Dysphagia	effortful swall... Mendelsohn swal...	20 Years - 70 Years	National Taiwan University Hospital

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