Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Symptoms and General Pathology

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Disease Progression

Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

All Drugs and Chemicals

Amino Acids

Tyrosine Kinase Inhibitors

Protein Kinase Inhibitors

Enzyme Inhibitors

Tyrosine

TKI combined with investigator's choice of chemotherapy regimen and subsequent line of treatment until rapid progression.

EGFR tyrosine kinase inhibitor

EGFR tyrosine kinase inhibitor with chemotherapy

Qiong Zhao, PhD

There have been reports suggesting that continuous administration of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is advantageous for patients in which gradual disease progression was observed after the establishment of clinical benefit from EGFR-TKIs. However, whether EGFR TKI with or without chemotherapy provides more survival benefit has not been formally evaluated.

We design this clinical trial to compare the efficacy of continuation of EGFR TKI with or without chemotherapy in patients beyond gradual progression.

Continuation of TKI With or Without Chemotherapy Beyond Gradual Progression

Phase II Study of Continuation of Tyrosine Kinase Inhibitor (TKI) With or Without Chemotherapy Beyond Gradual Progression in Advanced Non-small Cell Lung Cancer (NSCLC)

Zhejiang University

Chief of Department of Thoracic Oncology

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Continuation of TKI With or Without Chemotherapy Beyond Gradual Progression	NCT01998061	Non Small Cell ...	EGFR tyrosine k... EGFR tyrosine k...	18 Years - 75 Years	Zhejiang University
Continuation of TKI With or Without Chemotherapy Beyond Gradual Progression	NCT01998061	Non Small Cell ...	EGFR tyrosine k... EGFR tyrosine k...	18 Years - 75 Years	Zhejiang University

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