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Pneumonia, Viral

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Coronaviridae Infections

Nidovirales Infections

RNA Virus Infections

Lung Diseases

Respiratory Tract Diseases

Pierce Chow, MD, PhD

This study aims to look at the impact on patient outcomes arising from measures implemented during the COVID-19 pandemic. The information and knowledge from this study will be useful for the management and allocation of hospital resources and patients in tne event of a disease outbreak.

Impact of Measures Taken to Contain COVID-19 on Hospital Surgical Care Services and Clinical Outcomes

These patients are classified according to the institution, type of surgical procedures, the medical condition and the dates of surgical treatment. The study will be compared across four time periods.

The study focus on surgical indices for selected high-volume cancer and non-cancer diagnoses over the period 1st January2020 to 31 December 2020 and compare them with similar indices across the same period of time in the preceding 3 years in particular, for the following surgical procedures:

1. Surgeries for the following cancer diagnoses:

   1. breast cancer, \[XIV- N60, no malignancy\], \[Malignant, IINeoplasms- C50\], colorectal cancer, \[C18, 19, 20\],
   2. hepatocellular carcinoma, \[C22\]
2. Selected non-cancer surgeries:

   1. Cholecystectomy
   2. Abdominal hernia repair

National Medical Research Council (NMRC), Singapore

National Cancer Centre, Singapore

Participants will be given 2 servings immunonutrition daily for five (5) days before tentative elective surgery. ERAS protocol will implement and continued 2 servings of immunonutrition for post-operative seven (7) days.

Participants will be on usual diet intake before tentative elective surgery. ERAS protocol will implement and will be prescribed 2 servings of polymeric formula daily only if unable to finish 75% of the diet served in ward.

Participant will prescribed with 2 servings of immunonutrition supplement 5 days before surgery and 7 days after surgery

Immunonutrition oral nutrition supplementation

ChiouYi Ho

Zulfitri 'Azuan Mat Daud

The goal of this clinical trial is to compare the effect of perioperative immunonutrition supplement in gynecologic cancer patients. The main questions it aims to answer are:

* is there any difference in the nutritional outcomes and functional outcomes between intervention and conventional groups?
* is there any difference in the post-surgical outcomes between intervention and conventional groups?

Participants (intervention) will be provided the immunonutrition supplement before and after operation.

Researchers will compare intervention group with conventional group to see if there is any difference in postoperative outcomes.

The clinical trial aims to determine the effectiveness of perioperative IMN intervention on postoperative outcomes among GC patients under Enhanced Recovery after Surgery (ERAS) setting. Patients will prescribed with immunonutrition supplement before and after surgery.

After consented, participants will be randomized into two groups: the intervention group and conventional group during consultation in multidisciplinary clinic.

Perioperative Immunonutrition Under Enhanced Recovery After Surgery

Perioperative Immunonutrition Among Gynecological Cancer Patients Under Enhanced Recovery After Surgery

body composition analyzer; weight in kg; fat free mass in kg; fat mass in kg; muscle mass in kg; height in meter

Concentration of immunoglobulin G; Concentration of immunoglobulin A; Concentration of immunoglobulin M

handgrip strength in kg via Jammar dynamometer

questionnaire 10-item perceived stress scale (PSS-10) form

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Impact of Measures Taken to Contain COVID-19 on Hospital Surgical Care Services and Clinical Outcomes	NCT04961489	Surgery		21 Years - 100 Years	National Cancer Centre, Singapore
Perioperative Immunonutrition Under Enhanced Recovery After Surgery	NCT06039306	Gynecological C... Elective Surger...	Immunonutrition...	18 Years - 80 Years	Universiti Putra Malaysia
Perioperative Immunonutrition Under Enhanced Recovery After Surgery	NCT06039306	Gynecological C... Elective Surger...	Immunonutrition...	18 Years - 80 Years	Universiti Putra Malaysia
Impact of Measures Taken to Contain COVID-19 on Hospital Surgical Care Services and Clinical Outcomes	NCT04961489	Surgery		21 Years - 100 Years	National Cancer Centre, Singapore

Spots Global Cancer Trial Database for elective surgery