Neoplasms

Digestive System Diseases

All Conditions

Rare Diseases

Esophageal Neoplasms

Carcinoma

Carcinoma, Squamous Cell

Esophageal Squamous Cell Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Squamous Cell

Gastrointestinal Neoplasms

Digestive System Neoplasms

Head and Neck Neoplasms

Gastrointestinal Diseases

Esophageal Diseases

Esophageal Cancer

chemoradiotherapy with Enteral Nutrition intervention

Patients in the Trial Group received concurrent chemoradiotherapy and standardized, whole-course enteral nutrition management.

Enteral nutrition

Patients receive intensity modulated radiation therapy(IMRT) from week 1 to week 7,once a day, 5 times per week.

Radiotherapy dose：95% gross tumor volume（GTV-T） 60-66 Gy /30-33f，GTV-N 60-66 Gy /30-33f，CTV-T 50-54 Gy /25-27f，CTV-N 50-54 Gy /25-27f.

radiotherapy

TAO LI, MD, PhD

This is a randomized, prospective, multicenter study.

This is a randomized, prospective, multicenter study. The aim of this study was to compare the changes of body weight,survival,toxicity,quality of life and opportunistic infection frequency in Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma between and after chemoradiotherapy with or without enteral nutrition therapy.

Chemoradiotherapy With or Without Enteral Nutrition for Locally Advanced Thoracic Esophageal Carcinoma

A Prospective, Multicenter, Randomized Controlled Study to Compare Chemoradiotherapy With or Without Enteral Nutrition Intervention for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

Body weight change from baseline to the end of treatment = body weight at the end of treatment - baseline body weight.

Maximum body weight change during treatment= the lowest body weight during treatment - baseline body weight.

Grade 3-5 adverse events as assessed by NCI Common Toxicity Criteria for Adverse Effects (CTCAE) v3.0 andthe criteria of the Radiation Therapy Oncology Group ，such as esophagitis、pneumonitis 、hematologic toxicity and infection rate

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Chemoradiotherapy With or Without Enteral Nutrition for Locally Advanced Thoracic Esophageal Carcinoma	NCT02399306	Esophageal Squa... Enteral Nutriti... Chemoradiothera...	Enteral nutriti... radiotherapy	18 Years - 75 Years	Sichuan Cancer Hospital and Research Institute
Chemoradiotherapy With or Without Enteral Nutrition for Locally Advanced Thoracic Esophageal Carcinoma	NCT02399306	Esophageal Squa... Enteral Nutriti... Chemoradiothera...	Enteral nutriti... radiotherapy	18 Years - 75 Years	Sichuan Cancer Hospital and Research Institute

Spots Global Cancer Trial Database for enteral nutrition therapy