Adjuvants, Anesthesia

Central Nervous System Depressants

Psychotropic Drugs

All Drugs and Chemicals

Gastrointestinal Agents

Antineoplastic Agents

Midazolam

Omeprazole

Epothilone B

Epothilones

Antacids

Anti-Ulcer Agents

Proton Pump Inhibitors

Enzyme Inhibitors

Tubulin Modulators

Antimitotic Agents

Patupilone and Omeprazole

Patupilone + Midalzolam

Novartis Pharmaceuticals

The purpose of this study is to evaluate the potential inhibitory effects of patupilone on metabolism using midazolam and omeprazole as the respective probe drugs.

Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies

An Open Label Phase I Study to Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies

Symptoms and General Pathology

All Conditions

Neoplasms

Digestive System Diseases

Diarrhea

Colonic Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Herbal and Botanical

Cola

EPO906 (patupilone)

This study is exploring different administration schedules (short versus prolonged infusion) to optimize the safety and efficacy profile of EPO906A (patupilone) in patients with pretreated advanced colon cancer.

Dose-Escalation Study in Advanced Colon Cancer Patients

EPO906 Phase I 6-arm Trial to Optimize Administration Exploring Single Dose Bolus and Continuous Infusion Over 1 or 5 Days Every 3 or 4 Weeks in Patients With Pretreated Advanced Colon Cancer With Nutritional Support Treatment and Intensive Management of Diarrhea

Anticoagulants

Warfarin

Patupilone

To evaluate the effects of patupilone on the pharmacokinetics of warfarin in patients with advanced malignancies.

The Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies

An Open Label Phase I Study to Evaluate the Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies-extension Study

External Affairs

Patupilone + Omeprazole

The purpose of this extension study is to evaluate the potential inhibitory effects of patupilone on metabolism using midazolam and omeprazole as the respective probe drugs.

Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension)

An Open Label Phase I Study to Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension)

Respiratory Tract (Lung and Bronchial) Diseases

Nervous System Diseases

Recurrence

Carcinoma, Non-Small-Cell Lung

Brain Neoplasms

Neoplasm Metastasis

Lung Neoplasms

Carcinoma

Neoplasms, Second Primary

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Neoplastic Processes

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

The study objective is to evaluate the safety and efficacy of patupilone with respect to early progression and response of patients with non-small cell lung cancer (NSCLC) metastatic to the brain, who have progressed after chemotherapy, surgery and/or radiation.

Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer

An Open-label, Multi-center, Phase II Study to Evaluate the Activity of Patupilone (EPO906), in the Treatment of Recurrent or Progressive Brain Metastases in Patients With Non-small Cell Lung Cancer.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies	NCT00420615	Solid Tumors	Patupilone and ... Patupilone + Mi...	18 Years -	Novartis
Dose-Escalation Study in Advanced Colon Cancer Patients	NCT00969046	Colon Cancer	EPO906 (patupil...	18 Years -	Novartis
The Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies	NCT00468260	Advanced Malign...	Patupilone	18 Years -	Novartis
Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension)	NCT00442741	Solid Tumors	Patupilone Patupilone + Om...	18 Years -	Novartis
Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer	NCT00219297	Brain Metastasi... Non-small Cell ...	Patupilone	18 Years -	Novartis

Spots Global Cancer Trial Database for epo906

Every month we try and update this database with for epo906 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for epo906

Every month we try and update this database with for epo906 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for epo906 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.