Spots Global Cancer Trial Database for brain metastasis
Every month we try and update this database with for brain metastasis cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases | NCT04700748 | Radiotherapy Brain Metastase... Sensitivity Radionecrosis | Brain metastase... | 18 Years - | Lund University Hospital | |
| Concurrent Fluorescence and Sonographically Guided Eradication of Contrast-enhancing Gliomas and Metastases | NCT05474573 | Glioma, Maligna... Metastases to B... | Combined ultras... Fluorescence-gu... | 18 Years - 79 Years | Sklifosovsky Institute of Emergency Care | |
| Safety Evaluation of a Combination of Brain Radiation Therapy and Bevacizumab (Avastin®) for Treatment of Brain Metastasis | NCT01332929 | Metastatic Mali... | Bevacizumab | 18 Years - 70 Years | Centre Francois Baclesse | |
| Nivo/Ipi Combination Therapy in Symptomatic Brain Metastases | NCT02621515 | Melanoma Brain Metastasi... | Nivolumab | 18 Years - | University Medical Center Groningen | |
| Vemurafenib and Cobimetinib Combination in BRAF Mutated Melanoma With Brain Metastasis | NCT02537600 | Malignant Melan... | Cobimetinib + V... | 18 Years - | Center Eugene Marquis | |
| SHR-A1921 Combined With Bevacizumab in Triple-negative Breast Cancer With Brain Metastases | NCT06210438 | TNBC Brain Metastasi... | SHR-A1921 + Bev... | 18 Years - | Fudan University | |
| Evaluation of 68-GaNOTA-Anti-HER2 VHH1 Uptake in Brain Metastasis of Cancer Patients | NCT03331601 | Carcinoma Receptor, ErbB-... | 68GaNOTA-Anti-H... | 18 Years - | Universitair Ziekenhuis Brussel | |
| Clinical Trial of YH25448 in Patients With EGFR Mutation Positive Advanced NSCLC | NCT03046992 | EGFR Gene Mutat... | YH25448 | 20 Years - | Yuhan Corporation | |
| Study of SBRT Efficacy on Intra and Extra -Cranial Tumors or Metastasis in Pediatrics Population (SBRT Pediatrics) | NCT02013297 | Brain Metastasi... Spinal Tumors Lung Tumors Ependymoma | SBRT treatment | 18 Months - 20 Years | Centre Leon Berard | |
| Study Comparing Investigational Drug HBI-8000 Combined With Nivolumab vs. Nivolumab in Patients With Advanced Melanoma | NCT04674683 | Unresectable or... Progressive Bra... | HBI-8000 in com... Placebo in comb... | 12 Years - | HUYABIO International, LLC. | |
| Cambridge Brain Mets Trial 1 | NCT02768337 | Lung Cancer Breast Cancer Brain Cancer Advanced Breast... Advanced Lung C... | Afatinib 2 Gy targeted r... 4 Gy targeted r... | 18 Years - | Cambridge University Hospitals NHS Foundation Trust | |
| Hippocampal-sparing Whole Brain Radiotherapy for Brain Metastases From Breast Cancer | NCT03002532 | Breast Cancer M... Brain Metastase... | whole brain rad... | 18 Years - 75 Years | Affiliated Hospital to Academy of Military Medical Sciences | |
| Melanoma Metastasized to the Brain and Steroids | NCT03563729 | Malignant Melan... | Pembrolizumab I... Ipilimumab Inje... Nivolumab Injec... Encorafenib Binimetinib Dabrafenib Trametinib | 18 Years - | Herlev Hospital | |
| SH L 562BB Phase II/III Dose Justification and Gadoteridol-controlled Comparative Study | NCT00522951 | Brain Metastase... | Gadobutrol (Gad... Gadobutrol (Gad... ProHance | 20 Years - | Bayer | |
| Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S | NCT04430842 | Astrocytoma Brain Cancer Brain Metastase... Bladder Cancer Breast Cancer Cervical Cancer Cholangiocarcin... Colorectal Canc... Esophagus Cance... Gastric Cancer Head and Neck C... Kidney Cancer Liver Cancer Lung Cancer Melanoma Ovarian Cancer Pancreatic Canc... Pleural Mesothe... Prostate Cancer Sarcoma Tongue Cancer Thymic Carcinom... Urinary Tract C... | QBS10072S | 18 Years - | Quadriga Biosciences, Inc. | |
| Can Hybrid PET-MRI Differentiate Between Radiation Effects and Disease Progression? | NCT03068520 | Brain Tumor | PET MR | 18 Years - 70 Years | Assuta Medical Center | |
| Safety Evaluation of a Combination of Brain Radiation Therapy and Bevacizumab (Avastin®) for Treatment of Brain Metastasis | NCT01332929 | Metastatic Mali... | Bevacizumab | 18 Years - 70 Years | Centre Francois Baclesse | |
| Toripalimab Combined With Anlotinib and SBRT in Patients With Untreated Brain Metastases of Driven Gene-negative NSCLC | NCT05021328 | NSCLC | Toripalimab Anlotinib SBRT 7Gy✖️5 QD | 18 Years - | Hubei Cancer Hospital | |
| A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis | NCT01173497 | Estrogen Recept... Progesterone Re... Human Epidermal... Brain Metastase... | INIPARIB + irin... | 21 Years - | Sanofi | |
| Methionine and PBR28-PET (Peripheral Benzodiazepine Receptors) in Brain Metastases Following Radiosurgery | NCT02433171 | Brain Metastasi... | Standard of Car... | 18 Years - 80 Years | Yale University | |
| Proteome-based Immunotherapy of Brain Metastases From Breast Cancer | NCT01782274 | Neoplasm Metast... | Dendritic vacci... Dendritic vacci... | 18 Years - 70 Years | NeuroVita Clinic | |
| Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer | NCT01942980 | Breast Cancer Brain Metastasi... | Radiation thera... | 18 Years - | Institut Paoli-Calmettes | |
| Hypofractionated Stereotactic Radiation Therapy of Brain Metastases: Evaluation of Whole-brain Radiotherapy | NCT02913534 | Brain Metastasi... | whole brain rad... | 18 Years - | Institut de Cancérologie de Lorraine | |
| General Anesthesia Versus Awake Surgery in Resection of Gliomas and Metastases of Motor Areas | NCT05485038 | Gliomas Benign Glioma, Maligna... Metastases to B... | Tumor resection... Tumor resection... | 18 Years - 69 Years | Sklifosovsky Institute of Emergency Care | |
| Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer | NCT02448992 | Non-Small-Cell ... Brain Metastasi... | hippocampal-spa... | 18 Years - 80 Years | Chang Gung Memorial Hospital | |
| Clinical Trial of YH25448 in Patients With EGFR Mutation Positive Advanced NSCLC | NCT03046992 | EGFR Gene Mutat... | YH25448 | 20 Years - | Yuhan Corporation | |
| Vorinostat and Concurrent Whole Brain Radiotherapy for Brain Metastasis | NCT01600742 | Brain Metastasi... | Vorinostat Placebo | 20 Years - | National Taiwan University Hospital | |
| EGFR-TKI Concurrent With/Without WBRT in Brain Metastasis From NSCLC | NCT02714010 | Non-Small Cell ... | EGFR-TKI whole brain rad... | 18 Years - 75 Years | Sun Yat-sen University | |
| A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive Function Decline | NCT02504788 | Brain Metastasi... Brain Metastase... | hippocampal-spa... | 18 Years - 84 Years | Chang Gung Memorial Hospital | |
| Evaluation of Cabazitaxel in Patients With Brain Metastasis Secondary to Breast Cancer and NSCLC | NCT01913067 | Brain Metastasi... Breast Cancer Non Small Cell ... | Cabazitaxel Contrast-enhanc... | 18 Years - | Jules Bordet Institute | |
| Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis | NCT01281696 | Breast Neoplasm... Leptomeningeal ... Brain Metastase... | Bevacizumab, et... Intrathecal met... | 18 Years - 75 Years | National Taiwan University Hospital | |
| Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer | NCT02681549 | Melanoma Non-small Cell ... Brain Metastasi... | Pembrolizumab p... | 18 Years - | Yale University | |
| Value of Screening MRI Brain in Stage IV Non-small Cell Lung Cancer | NCT05864794 | Non Small Cell ... | MRI | 18 Years - | University Medical Center Groningen | |
| Magnevist (SH L 451A) Intra-individual Dose Comparison Study in Patients With Brain Metastasis | NCT00681551 | Brain Neoplasms | Magnevist (SH L... Magnevist (SH L... | 20 Years - | Bayer | |
| Efficacy of Gefitinib for Brain Metastasis of Non-Small Cell Lung Cancer | NCT00614809 | Non-Small Cell ... Brain Metastasi... | gefitinib | 18 Years - | GuangdongPPH | |
| MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer | NCT06247449 | Breast Cancer | Brain imaging Analysis of cir... Testing Morbidi... | 18 Years - | Sunnybrook Health Sciences Centre | |
| REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis | NCT06315010 | NSCLC Brain Metastase... ROS1 Gene Rearr... | Repotrectinib | 18 Years - | MedSIR | |
| Study of Whole-brain Irradiation With Chloroquine for Brain Metastases | NCT01894633 | Brain Metastasi... | Chloroquine Total brain rad... | 46 Years - 61 Years | Instituto Nacional de Cancerologia de Mexico | |
| Hypofractionated Stereotactic Radiosurgery in Treating Patients With Large Brain Metastasis | NCT01705548 | Metastatic Mali... Unspecified Adu... | Hypofractionate... | 18 Years - | Emory University | |
| Prophylactic Cranial Irradiation (PCI) Versus no PCI in Non Small Cell Lung Cancer After a Response to Chemotherapy | NCT00745797 | Brain Metastase... | Radiotherapy | 18 Years - 75 Years | Chinese Society of Lung Cancer | |
| The Continuation of Erlotinib | NCT01130779 | Non-small Cell ... | Erlotinib (TARC... | 18 Years - | Samsung Medical Center | |
| Study of Whole-brain Irradiation With Chloroquine for Brain Metastases | NCT01894633 | Brain Metastasi... | Chloroquine Total brain rad... | 46 Years - 61 Years | Instituto Nacional de Cancerologia de Mexico | |
| Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study | NCT04690348 | Recurrent Brain... | Craniotomy Cesium-131 brac... | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| A Phase II Trial of Upfront Radiotherapy Plus Almonertinib for Epidermal Growth Factor Receptor(EGFR)-Mutant Non-small-cell Lung Cancer(NSCLC) Patients With Brain Metastases | NCT04643847 | EGFR Positive N... Brain Metastase... | Almonertinib | 18 Years - | First People's Hospital of Hangzhou | |
| Melanoma Metastasized to the Brain and Steroids | NCT03563729 | Malignant Melan... | Pembrolizumab I... Ipilimumab Inje... Nivolumab Injec... Encorafenib Binimetinib Dabrafenib Trametinib | 18 Years - | Herlev Hospital | |
| SHR-A1921 Combined With Bevacizumab in Triple-negative Breast Cancer With Brain Metastases | NCT06210438 | TNBC Brain Metastasi... | SHR-A1921 + Bev... | 18 Years - | Fudan University | |
| Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium | NCT00756639 | Bladder Cancer | Prophylactic Cr... Brain X-ray | 18 Years - | M.D. Anderson Cancer Center | |
| Icotinib or Whole Brain Irradiation in EGFR-mutant Lung Cancer | NCT01724801 | Brain Metastasi... Non Small Cell ... | whole brain rad... Icotinib | 18 Years - 75 Years | Guangdong Association of Clinical Trials | |
| General Anesthesia Versus Awake Surgery in Resection of Gliomas and Metastases of Motor Areas | NCT05485038 | Gliomas Benign Glioma, Maligna... Metastases to B... | Tumor resection... Tumor resection... | 18 Years - 69 Years | Sklifosovsky Institute of Emergency Care | |
| Pharmacokinetics of Systemic Anti-Cancer Therapies in the Cerebrospinal Fluid (CSF) of Patients With Advanced Cancer | NCT02580045 | Metastatic Canc... Advanced Cancer Brain Metastasi... | 18 Years - | Duke University | ||
| Melanoma Metastasized to the Brain and Steroids | NCT03563729 | Malignant Melan... | Pembrolizumab I... Ipilimumab Inje... Nivolumab Injec... Encorafenib Binimetinib Dabrafenib Trametinib | 18 Years - | Herlev Hospital | |
| Phase I Trial of Stereotactic Radiosurgery Following Surgical Resection of Brain Metastases | NCT01395407 | Brain Metastasi... Neoplasm | Radiosurgery do... | 18 Years - | Emory University | |
| Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases | NCT02279992 | Glioma Brain Neoplasms Brain Metastasi... | Vardenafil Carboplatin | 18 Years - | Cedars-Sinai Medical Center | |
| Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients | NCT03694938 | Metastatic Colo... | Magnetic resona... | 18 Years - | Poitiers University Hospital | |
| IDO2 Genetic Status Informs the Neoadjuvant Efficacy of Chloroquine (CQ) in Brain Metastasis Radiotherapy | NCT01727531 | Brain Metastasi... | Chloroquine dip... | 18 Years - | Main Line Health | |
| Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial | NCT03075072 | Brain Metastase... | Whole brain rad... Stereotactic ra... | 18 Years - 80 Years | Dana-Farber Cancer Institute | |
| Multi-Parametric Quantitative MR Imaging in Evaluation of Brain Tumors | NCT02956291 | Brain Tumor | Magnetic Resona... | 18 Years - | Case Comprehensive Cancer Center | |
| Temozolomide, Thalidomide, and Lomustine (TTL) in Melanoma Patients | NCT00527657 | Brain Neoplasms Melanoma | Lomustine Temozolomide Thalidomide | 18 Years - | M.D. Anderson Cancer Center | |
| Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors | NCT01324635 | Recurrent Gliom... High-grade Meni... Brain Metastasi... | Panobinostat Stereotactic bo... Quality-of-life... Stereotactic ra... | 18 Years - | Thomas Jefferson University | |
| Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients | NCT03694938 | Metastatic Colo... | Magnetic resona... | 18 Years - | Poitiers University Hospital | |
| Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis | NCT01281696 | Breast Neoplasm... Leptomeningeal ... Brain Metastase... | Bevacizumab, et... Intrathecal met... | 18 Years - 75 Years | National Taiwan University Hospital | |
| Surgery Versus Radiosurgery for the Treatment of Single Brain Metastases | NCT01295970 | Patients With a... | Surgery Stereotactic Ra... | 19 Years - | University Health Network, Toronto | |
| Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium | NCT00756639 | Bladder Cancer | Prophylactic Cr... Brain X-ray | 18 Years - | M.D. Anderson Cancer Center | |
| Brain Mets - Capecitabine Plus Sunitinib and WBRT | NCT00570908 | Breast Cancer | sunitinib capecitabine WBRT | 18 Years - | Baylor Breast Care Center | |
| Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases | NCT01445483 | Brain Metastasi... Cancer | 18 Years - | National Institutes of Health Clinical Center (CC) | ||
| Vorinostat and Concurrent Whole Brain Radiotherapy for Brain Metastasis | NCT01600742 | Brain Metastasi... | Vorinostat Placebo | 20 Years - | National Taiwan University Hospital | |
| Nilatinib Maleate Tablets Combined With Capecitabine in the Treatment of HER2-positive Advanced Esophageal/Esophagogastric Junction/Gastric Adenocarcinoma With Brain Metastases | NCT06374888 | Her2-positive A... | Neratinib malea... | 18 Years - | Convalife (Shanghai) Co., Ltd. | |
| Prospective Randomized Trial Between WBRT Plus SRS Versus SRS Alone for 1-4 Brain Metastases | NCT00406835 | Brain Metastasi... | Whole-Brain Rad... | 18 Years - | Hokkaido University Hospital | |
| Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis | NCT01363557 | EGFR-mutated Lu... Brain Metastasi... | whole brain rad... Gefitinib (IRES... | 18 Years - | Assistance Publique - Hôpitaux de Paris | |
| Intraoperative Sonographically Versus Fluorescence-guided Resection of Contrast-enhancing Gliomas and Brain Metastases | NCT05475522 | Gliomas, Malign... Metastases to B... | Ultrasound guid... 5-aminolevulini... | 18 Years - 79 Years | Sklifosovsky Institute of Emergency Care | |
| Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer | NCT02681549 | Melanoma Non-small Cell ... Brain Metastasi... | Pembrolizumab p... | 18 Years - | Yale University | |
| Ipilimumab Combined With a Stereotactic Radiosurgery in Melanoma Patients With Brain Metastases | NCT02662725 | Melanoma Brain Metastasi... | IPILIMUMAB Stereotactic ra... | 18 Years - | University Hospital, Lille | |
| Stereotactic Radiotherapy in Oligometastatic Brain Disease: a Randomised Phase III Study Comparing Hypofractionated Stereotactic Radiation Therapy (3*10 Gy) to the Historical Single-dose Radiosurgery (1*20 to 25 Gy) With Medico-economic Evaluation. | NCT05102747 | Brain Metastasi... Oligoprogressio... | Hypofractionate... Historical sing... | 18 Years - | Centre Francois Baclesse | |
| Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors | NCT01324635 | Recurrent Gliom... High-grade Meni... Brain Metastasi... | Panobinostat Stereotactic bo... Quality-of-life... Stereotactic ra... | 18 Years - | Thomas Jefferson University | |
| Neurocognitive Impact and Dose-Effect Relationship of Hippocampal Avoidance During Whole Brain Radiotherapy Plus Simultaneous Integrated Boost - A Prospective Follow-up Study | NCT03223675 | Brain Metastasi... Brain Metastase... | hippocampal-spa... | 20 Years - 84 Years | Chang Gung Memorial Hospital | |
| Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis | NCT01363557 | EGFR-mutated Lu... Brain Metastasi... | whole brain rad... Gefitinib (IRES... | 18 Years - | Assistance Publique - Hôpitaux de Paris | |
| T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery | NCT03190967 | Breast Cancer Brain Metastasi... Brain Cancer | T-DM1 TMZ | 18 Years - | National Institutes of Health Clinical Center (CC) | |
| Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium | NCT00756639 | Bladder Cancer | Prophylactic Cr... Brain X-ray | 18 Years - | M.D. Anderson Cancer Center | |
| VEGFRs Predict Bevacizumab Benefit in Advanced Non Small Cell Lung Cancer | NCT01891708 | Non Small Cell ... Brain Metastasi... | bevacizumab, st... | 18 Years - 75 Years | Huazhong University of Science and Technology | |
| PCI in Advanced Triple Negative Breast Cancer Patients Who Response to 1st Line Chemotherapy | NCT02448576 | Breast Cancer Brain Metastasi... | prophylactic cr... | 18 Years - 65 Years | Sun Yat-sen University |
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