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Esophageal Cancer

Kuaile Zhao

Kuaile Zhao, MD

Radiotherapy plays an important role in multidisciplinary treatment of esophageal cancer. Data from many laboratories indicate that local radiation produces systemic, immune-mediated anti¬tumour and, potentially, antimetastatic effects. Additionally, the combination of local radiotherapy and immune-modulation can augment local tumour control and cause distant (abscopal) antitumour effects through increased tumour-antigen release and antigen-presenting cell (APC) cross-presentation, improved dendritic-cell (DC) function, and enhanced T cell priming. The generation of an effective antitumor immune response requires the presentation of tumor antigens to naïve CD8+ cells in tumor-draining lymph nodes (TDLN) . Tumor-draining lymph nodes, however, are often subject to the immunosuppressive activity of tumor-derived factors, such as cytokines and other bioactive molecules from tumor cells and their associated leukocytes in the primary tumor site that contribute to the overriding of effective rejection mechanisms. Thus, in TDLN a T cell tolerance rather than a T cell activation often occurs, thereby preventing immune attack and facilitating local tumor progression.

In this study, the investigators collect clinical and biological evidence to interpret the impact of radiotherapy on tumor regression and immunity, and identify key molecular features and immune landscape patterns to characterize patients sensitive/resistant to radiotherapy; and define the dynamic changes occurring in TME and lymph node after radiotherapy.

Histological specimens of tumors derived from surgical or metastatic sites

The Study on the Mechanism of Radiotherapy-elicited Immune Response

Detailed mechanism of radiation-activated immunity under single-cell sequencing.gene mutations, copy number variants.

Fudan University

professor

Study title	NCT ID	Conditions	Eligibility	Organization
The Study on the Mechanism of Radiotherapy-elicited Immune Response	NCT06393140	Esophageal Carc... Radiotherapy	18 Years -	Fudan University
The Study on the Mechanism of Radiotherapy-elicited Immune Response	NCT06393140	Esophageal Carc... Radiotherapy	18 Years -	Fudan University
The Study on the Mechanism of Radiotherapy-elicited Immune Response	NCT06393140	Esophageal Carc... Radiotherapy	18 Years -	Fudan University

Spots Global Cancer Trial Database for esophageal carcinoma salivary gland type