Exercise treatment will consist of individualized walking delivered up to 5 times weekly. Patients in all cohorts will receive one dose of exercise (i.e., \~300 mins/wk following a non-linear dosing schedule) in both cohorts. Patients will have the option to receive exercise treatment at MSK or at their residence. Home-based exercise will be implemented and monitored using a telemedicine approach (i.e.,TeleEx) established in the Exercise-Oncology (ExOnc) Service

Exercise treatment will consist of individualized walking delivered up to 5 times weekly. This trial will evaluate one dose of exercise (i.e., \~300 mins/wk following a non-linear dosing schedule) in both cohorts. Patients will have the option to receive exercise treatment at MSK or at their residence. Home-based exercise will be implemented and monitored using a telemedicine approach (i.e.,TeleEx) established in the Exercise-Oncology (ExOnc) Service

exercise (walking)

Plasma samples will be obtained at baseline.

plasma samples

blood draw

Lee Jones, PhD

Jessica Scott, PhD

Paul C Boutros, PhD

Paul Boutros, PhD

Suzanne Carlisle

Jason Locasale, PhD

This study is being done to answer the following question: Will aerobic exercise (exercise that stimulates and strengthens the heart and lungs, and improves the body's use of oxygen) change the biomarkers (signs of disease) found in the blood?

For cohort 3 only. Men with histologically-confirmed localized prostate cancer undergoing active surveillance. Both patients and investigators will be fully blinded to the ctDNA status of patients during study participation.

Researching the Effect of Aerobic Exercise on Cancer

Exercise as Interception Therapy: A "Proof-of-Concept" Digitized Trail

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

measured by targeted CH panel in peripheral blood

measured by the amount of circulating tumor DNA (ctDNA)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Researching the Effect of Aerobic Exercise on Cancer	NCT03996239	Cancer	exercise (walki... plasma samples blood draw	18 Years -	Memorial Sloan Kettering Cancer Center
Researching the Effect of Aerobic Exercise on Cancer	NCT03996239	Cancer	exercise (walki... plasma samples blood draw	18 Years -	Memorial Sloan Kettering Cancer Center
Researching the Effect of Aerobic Exercise on Cancer	NCT03996239	Cancer	exercise (walki... plasma samples blood draw	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for exercise (walking)