Symptoms and General Pathology

All Conditions

Syndrome

Frailty

exercise and nutritional support program during an active support phase (0 to 6 months) followed by an empowerment phase (from 6 to 12 months)

exercise and nutritional support

Gaëtan Gavazzi, MD, PhD

Stéphane Mouret, PhD

Decrease the prevalence of frailty syndrome in individuals with complete response of cancer.

Frailty Syndrome of Post-cancer Treatment Eldery Patients

Impact of Exercise and Nutritional Support on the Frailty Syndrome of Eldery Patients in Phase of Post-cancer Treatment

evolution of individual frailty during a multimodal intervention (physical and nutritional activity) according to the Fried's criteria

The criterion determining the frail status is the Fried score classified into 3 categories: not frail; pre-frail; frail. A change from frail to pre-frail or to not frail will be considered as an improvement. Measurements of the Frailty score and other markers on nutrition and APA will be carried out at month 0 (basic measurements), then measured at month 6 (end of APA and nutritionist support) and at month12 (6 months after empowerment). All of health markers collected during the basic assessment, changes in parameters (month 6) and compliance with APA and nutrition support (from Month 1 to Month 6 then between Month 6 and Month 12) will be tested as variables potentially predictive of an improvement in the frailty syndrome.

measurement of VO2peak + ventilatory thresholds measured in a stress test, muscle strength/endurance (number of chair raises for 30 seconds), walking speed (10-meter walking test, 6-minute walk test), balance (Tinette score), coordination (functional mobility test), cardio-respiratory endurance (heart rate measurement in relation to pedaling power)

nutritional parameters measured at each time frame for weight, VAS appetite score, MNA score, nutritional calculation (food survey and self-questionnaire), bio impedancemetry and biomarkers of nutrition (levels of albumin, prealbumin, C reactive protein, CBC, liver and kidney function)

Adherence to APA support program throughout the study will be evaluated by measurements and sum of multiple parameters: number of sessions recorded on the heart rate monitor, average energy expenditure (in kcal) measured by the heart rate monitor,number of sets of exercises performed relative to the number of exercises recommended for muscle strengthening recorded in the patient notebook, CESS scale to assess beliefs about cancer patients and physical activity

comparison between active support phase and empowerment phase with food self-questionnaire

number of monthly patient connections to heart rate monitor; evaluation of the completion of patient notebook

Assessment of quality of life with EQ-5D questionnaire by comparison to the basal state (M0).

a series of qualitative interviews with a panel of 15 patients, during 2 interview sessions: 1 after support phase and 1 at the end of autonomy phase. Interview will collect past/current socio-professional life, socialization in physical activity and nutrition.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Frailty Syndrome of Post-cancer Treatment Eldery Patients	NCT04746768	Frailty Syndrom... Exercise Nutritional Sup... Cancer	exercise and nu...	70 Years -	University Hospital, Grenoble
Frailty Syndrome of Post-cancer Treatment Eldery Patients	NCT04746768	Frailty Syndrom... Exercise Nutritional Sup... Cancer	exercise and nu...	70 Years -	University Hospital, Grenoble

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