Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

All subjects will meet a set amount of times with a personal trainer over the course of the study to participate in an exercise regimen.

Subjects will receive a personal exercise regimen based on their health history and individual capability.

Exercise regimen

G van Londen, MD, MS

The purpose is to examine the feasibility and preliminary effectiveness of the role of a personal trainer for non-metastatic breast cancer survivors to improve physical activity and well-being (in terms of quality of life).

After breast cancer treatment, many women are faced with effects of treatment such as changes in appearance, fatigue, and reduced quality of life as compared to the pre-disease state. An intervention to increase physical activity may be helpful to improve well-being and outcomes for women treated for breast cancer.

Feasibility Study of the Addition of a Personal Trainer to the Post-Treatment Regimen of Breast Cancer Survivors

This questionnaire asks about exercise habits.

This questionnaire will measure a person's perceived competence to engage in an activity

University of Pittsburgh

Assistant Professor

Nutritional and Metabolic Diseases

Symptoms and General Pathology

Obesity

Each patient will have a weekly goal of 2000 calories burned and 18 MET-hours of exercise which can be achieved in 4 to 7 hours of physical activity per week. Resistance training, using weight machines and aerobic training using treadmills, elliptical trainers and stationary bicycles, will be utilized in the intervention group.

The control group will receive basic information on physical activity but not be instructed.

Exercise Regimen

Breanne Eddington

Karen Milligan, MD

The proposed study compares the outcomes of a physical activity intervention begun at diagnosis, continuing through active cancer treatment and into six months of survivorship compared to the outcomes of a control group receiving limited information on activity.

Patients (with stage 0 to stage III breast cancer)receiving chemotherapy, radiation or both chemotherapy and radiation will be included in the study.Randomization will be stratified by disease stage at diagnosis, treatment modalities planned, and hormonal status. Each patient will have a weekly goal of 2000 calories burned and 18 MET-hours of exercise which can be achieved in 4 to 7 hours of physical activity per week. Resistance training, using weight machines and aerobic training using treadmills, elliptical trainers and stationary bicycles, will be utilized in the intervention group. The control group will receive basic information on physical activity but not be instructed. Any physical activity in this group will be self-reported. Change in C-reactive protein will be the primary endpoint. Changes in other laboratory values, DEXA measurements, and quality of life measurements will be secondary endpoints.

Breast Cancer Patients: A Breast Cancer Rehabilitation and Exercise Laboratory

Prescriptive Exercise Intervention During Active Treatment for Early Stage Breast Cancer Patients: A Breast Cancer Rehabilitation & Exercise Laboratory

The primary endpoint for this study change in C-reactive protein.

Compare changes in:

* Glucose
* Insulin
* Estradiol
* Testosterone

Body composition parameters and bone density will be assessed using Dual Energy X-ray Absorptiometry (DEXA) and compared between the two groups.

Quality of Life will be measured and compared between the groups

Comparing overall survival and progression free survival between groups.

Vons

Nevada Cancer Institute

Hypoglycemic Agents

All Drugs and Chemicals

Insulin

Insulin, Globin Zinc

One-on-One training with a personal trainer for 50 minutes twice a week using Nautilus machines for 16 weeks.

Strength training

Cardiovascular training at home for 30 minutes three times per week for 16 weeks.

Endurance training

Jennifer Ligibel, MD

The purpose of this study is to determine whether an exercise program comprised of strength and endurance training will lower fasting insulin levels in a group of breast cancer survivors. Insulin may be involved in the risk of breast cancer recurrence.

* All women taking part in this study will take part in an exercise program. Group A will start exercising immediately and Group B wil have a delay period of 16 weeks before starting to exercise so investigators can look at the changes in insulin levels that occur in a women who is not exercising.
* The exercise program will be made up of two parts: strength (or weight) training and cardiovascular exercise. The strength exercise will take place at a gym close to Dana-Farber Cancer Institute. Patients will work one on one with a personal trainer twice a week for 50 minutes. During each of these sessions, participants will have a brief warm up period and then will perform a series of Nautilus machine-based exercises under the guidance of the personal trainer. The goal of each session will be to increase strength by increasing weight lifted and repetitions.
* Participants will also do cardiovascular exercises on their own at home. Each participant will receive a pedometer and heart rate monitor. Women will be advised to exercise for at least 30 minutes three times per week on their own and will keep a journal recording how long and how intensively they exercised. Participants will receive weekly phone calls from the project manager to review the cardiovascular exercise.
* Women will undergo a series of measurements before and after the 16 week exercise intervention. They will be asked to fast for 12 hours prior to each of these measurement sessions. Measurements will include blood testing for insulin and glucose levels. Women will also be weighed, height will be measured, body composition will be computed using a noninvasive bioelectric impedance monitor, and hip/waist measurements will be taken. Group A participants will undergo testing at the time of enrolling in the study and after 16 weeks of exercise. Group B participants will undergo these tests after enrollment, after the 16 week waiting period and at the end of the exercise program.
* Participants will also complete two surveys by mail, 3 months and 9 months after completing the exercise portion of the protocol.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Feasibility Study of the Addition of a Personal Trainer to the Post-Treatment Regimen of Breast Cancer Survivors	NCT02770781	Breast Cancer	Exercise regime...	18 Years -	University of Pittsburgh
Breast Cancer Patients: A Breast Cancer Rehabilitation and Exercise Laboratory	NCT01157130	Early Stage Bre...	Exercise Regime...	18 Years -	Nevada Cancer Institute
Feasibility Study of the Addition of a Personal Trainer to the Post-Treatment Regimen of Breast Cancer Survivors	NCT02770781	Breast Cancer	Exercise regime...	18 Years -	University of Pittsburgh
Effects of Exercise Intervention on Insulin Levels in Breast Cancer Survivors	NCT00153894	Breast Cancer	Strength traini... Endurance train...	18 Years -	Dana-Farber Cancer Institute

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