Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Digestive System Diseases

Respiratory Tract (Lung and Bronchial) Diseases

Blood and Lymph Conditions

Immune System Diseases

Nervous System Diseases

Rare Diseases

Breast Neoplasms

Stomach Neoplasms

Lung Neoplasms

Lymphoma

Brain Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Stomach Diseases

Stomach Cancer

Lymphosarcoma

Healthy female urban residents in Shanghai between ages of 40-70.

Qing Lan, M.D.

A prospective cohort study is proposed to evaluate occupational and environmental risk factors for cancer among women in Shanghai, China. Approximately 75,000 women aged 40-69 who reside in eight geographically defined communities in two urban districts of Shanghai will be recruited via a community-based cancer education program. All eligible subjects will be invited by local health workers from the neighborhood health station to the clinic for an interview and selected anthropometric measurements. The interview will elicit information on demographic background, diet, lifestyle factors, medical history, lifetime occupational history and residential history for the past 20 years. In addition, the women will be asked for information on their husbands' current and usual occupations, and demographic and a few other exposure factors. A spot urine sample and 10 ml of blood will be collected from all cohort members and stored at -70 degrees C for future assays of urine metabolites and DNA and hemoglobin adducts of selected occupational and environmental carcinogens, and polymorphic genes encoding enzymes that are involved in metabolism of relevant carcinogens. Cohort members and their husbands will be followed for cancer outcomes through biennial recontact and linkage with files of the population-based Shanghai Cancer Registry, of the Shanghai Vital Statistics, and of the Shanghai Resident Registry. Medical records and pathology slides will be reviewed for all cancer cases to verify their diagnosis. Post-diagnostic blood samples will be obtained from all cohort members diagnosed with cancer during the follow-up period and stored for future methodologic and etiologic studies. The proposed initial study period is 5 years, with an average follow-up of about 3.5 years. We anticipate, however, that follow-up will continue for 10 years or more.

A prospective cohort study is proposed to evaluate occupational and environmental risk factors for cancer among women in Shanghai, China. Approximately 75,000 women aged 40-69 who reside in eight geographically defined communities in two urban districts of Shanghai will be recruited via a community-based cancer education program. All eligible subjects will be invited by local health workers from the neighborhood health station to the clinic for an interview and selected anthropometric measurements. The interview will elicit information on demographic background, diet, lifestyle factors, medical history, lifetime occupational history and residential history for the past 20 years. In addition, the women will be asked for information on their husbands' current and usual occupations, and demographic and a few other exposure factors. A spot urine sample and 10 ml of blood will be collected from all cohort members. Among participants who did not provide a blood sample, a buccal cell sample will be collected. All biological samples will be stored at -70 degrees C for future assays of genetic polymorphisms, urine metabolites and DNA and hemoglobin adducts of selected occupational and environmental carcinogenACs. Cohort members and their husbands will be followed for cancer outcomes through annual recontact and linkage with files of the population-based Shanghai Cancer Registry, of the Shanghai Vital Statistics, and of the Shanghai Resident Registry. Medical records and pathology slides will be reviewed for all cancer cases to verify their diagnosis. Post-diagnostic blood samples will be obtained from all cohort members diagnosed with cancer during the follow-up period and stored for future methodologic and etiologic studies. The proposed initial study period is 5 years, with an average follow-up of about 3.5 years. We anticipate, however, that follow-up will continue for 10 years or more.

A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women

Any cancer incidence, selected chronic diseases and all causemortality

National Cancer Institute (NCI)

Charles E Matthews, Ph.D.

In spite of long-standing hypothesis relating diet and physical activity to several cancers, diet and physical activity-cancer associations have been modest at best and often inconsistent in epidemiologic studies. Investigators around the world have become increasingly concerned that error in the measurement of both diet and physical activity is compromising our ability to detect these important but modest associations. Most commonly used diet and physical activity assessment methods have been based on a relatively small set of questions (e.g. 124 food items consumed or 5-10 physical activities in the past 12 months). Recent developments in computer technology provide an opportunity to use internet-based instruments to assess an individual s diet and physical activity more accurately and cost effectively.

In spite of long-standing hypothesis relating diet and physical activity to several cancers, diet and physical activity-cancer associations have been modest at best and often inconsistent in epidemiologic studies. Investigators around the world have become increasingly concerned that error in the measurement of both diet and physical activity is compromising our ability to detect these important but modest associations. Most commonly used diet and physical activity assessment methods have been based on a relatively small set of questions (e.g. 124 food items consumed or 5-10 physical activities in the past 12 months). Recent developments in computer technology provide an opportunity to use internet-based instruments to assess an individual s diet and physical activity more accurately and cost effectively.

NCI has been developing two web-based instruments, an automated self-administered 24-hour dietary recall (ASA24) and a physical activity 24-hour recall (ACT24), which can be administered several times over a year. Although these two instruments have the potential to qualitatively improve exposure assessment (at relatively low cost), they need to be evaluated for feasibility before being incorporated in cohorts on a large scale. Therefore, we propose to test ASA24 and ACT24 among AARP members aged 50 years and over to evaluate technical problems, determine response rates, and estimate the range of dietary intake and physical activity. In addition, we propose to include in this feasibility study two web-based versions of conventional questionnaires (lifestyle and medical history questionnaire and diet history questionnaire) as well as two software systems needed to conduct a web-based study (the automated Study Management System and Web Survey Management System). We will initially target 15,000 AARP members, expecting that approximately 2,000 individuals will agree to participate in the study and about 1,250 participants will complete ASA24 and ACT24 twice.

These web-based instruments and accompanying system tools represent a novel approach to carrying out diet and lifestyle research. The computerized, web-based study method can be applied to any observational study, large or small, case-control or cohort, as well as randomized controlled trials. This feasibility study will provide an opportunity to assess the feasibility of constructing large web-based cohort studies and characterize potential participants.

Feasibility Study of a Web-Based Automated Self-Administered 24-hour Dietary Recall (ASA 24) and a Physical Activity 24-hour Recall

Feasibility Study of a Web-Based Automated Self-Administered 24-hour Dietary Recall (ASA 24) and a Physical Activity 24-Hour Recall (ACT24)

Study title	NCT ID	Conditions	Eligibility	Organization
A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women	NCT00342004	Lung Cancer Non-Hodgkin Lym... Breast Cancer Stomach Cancer Brain Cancer	40 Years - 70 Years	National Institutes of Health Clinical Center (CC)
Feasibility Study of a Web-Based Automated Self-Administered 24-hour Dietary Recall (ASA 24) and a Physical Activity 24-hour Recall	NCT01164254	Cancer	50 Years - 75 Years	National Institutes of Health Clinical Center (CC)
A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women	NCT00342004	Lung Cancer Non-Hodgkin Lym... Breast Cancer Stomach Cancer Brain Cancer	40 Years - 70 Years	National Institutes of Health Clinical Center (CC)
A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women	NCT00342004	Lung Cancer Non-Hodgkin Lym... Breast Cancer Stomach Cancer Brain Cancer	40 Years - 70 Years	National Institutes of Health Clinical Center (CC)

Spots Global Cancer Trial Database for exposure assessment