Neoplasms

Symptoms and General Pathology

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Cysts

Ovarian Cysts

Pathological Conditions, Anatomical

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

All Drugs and Chemicals

Progestins

Dydrogesterone

Progesterone

Hormones

Hormone Antagonists

these patients will be offered Dydrogesterone 10 mg twice daily will be offered for 10 days , then they will be seen Post-menstrual or delayed menses for 1 week after treatment

those patients will be offered placebo tablets twice daily will be offered for 10 days , then they will be seen Post-menstrual or delayed menses for 1 week after treatment

Dydrogesterone 10 mg

Placebo Oral Tablet

amgad saber, bachelor

The aim of this study is to determine whether the use of progesterone only pills has a beneficial effect over the expectant management of functional ovarian cyst or not , through a sample of female patients within the reproductive years

An ovarian cyst is a common gynecological problem and is divided into 2 main categories; physiological and pathological In relative frequency, functional cysts account for about 24% of all ovarian cysts, benign cysts 70% and malignant 6% Functional cysts are the most common masses seen in the premenopausal ovary and are estimated to affect 8%-20% of reproductive-aged women

Pain or discomfort in the lower abdomen Severe pain from torsion (twisting) or rupture - Cyst rupture is characterized by sudden, sharp, unilateral pelvic pain; this can be associated with trauma, exercise, or coitus. Cyst rupture can lead to peritoneal signs, abdominal distention, and bleeding (which is usually self-limited) Discomfort with intercourse, particularly deep penetration Changes in bowel movements such as constipation Pelvic pressure causing tenesmus or urinary frequency Menstrual irregularities Precocious puberty and early menarche in young children Abdominal fullness and bloating Indigestion, heartburn, or early satiety Hyperpyrexia - This may result from some complications of ovarian cysts, such as ovarian torsion Adnexal or cervical motion tenderness In current clinical practice , gynecologists treat functional ovarian cysts with either oral Contraceptive pills or expectant management alone. we presume using progesterone only pills for treatment of functional ovarian cyst

The Efficacy of Progestins in Treatment of Functional Ovarian Cyst

ultrasound evaluation

Post-menstrual or delayed menses for 1 week after treatment Patients will be asked about residual symptoms Then TVUS if

1. resolved , another examination will be scheduled after 1 month post-menstrual
2. decreasing in size , another course of treatment will be offered
3. stationary or increasing ,patient will be offered COCs (0.15 mg levonorgestrel and 0.03 mg ethinyl estradiol)
4. complicated ( torsion or rupture ) , patient will be subjected to surgery

Assiut University

Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Efficacy of Progestins in Treatment of Functional Ovarian Cyst	NCT03456570	Functional Ovar... Progesterone	Dydrogesterone ... Placebo Oral Ta...	18 Years - 44 Years	Assiut University
The Efficacy of Progestins in Treatment of Functional Ovarian Cyst	NCT03456570	Functional Ovar... Progesterone	Dydrogesterone ... Placebo Oral Ta...	18 Years - 44 Years	Assiut University

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