Neoplasms

Digestive System Diseases

All Conditions

Nutritional and Metabolic Diseases

Symptoms and General Pathology

Rare Diseases

Stomach Neoplasms

Overweight

Obesity

Hypoxia

Ulcer

Polyps

Stomach Ulcer

Overnutrition

Nutrition Disorders

Body Weight

Gastrointestinal Diseases

Stomach Diseases

Signs and Symptoms, Respiratory

Peptic Ulcer

Duodenal Diseases

Intestinal Diseases

Stomach Cancer

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

Propofol

Hypnotics and Sedatives

Anesthetics, Intravenous

Anesthetics, General

Anesthesia induction:Propofol 1.5mg/kg Anesthesia maintenance: Propofol 0.75mg/kg

Anesthesia induction:ciprofol 0.4mg/kg Anesthesia maintenance: ciprofol 0.2mg/kg

The sedation of gastrointestinal endoscopy with Ciprofol

Ciprofol

The sedation of gastrointestinal endoscopy with Propofol

weifeng Yu, PhD

diansan Su, PhD

Zhen Hua

Yanhong Lian

Hui Wang

Diansan Su

Linzhong Zhang

Ciprofol is a new general anesthetic, which combine with γ- Aminobutyric acid-a (GABAA) receptor. Ciprofol has shown equivalent anesthetic efficacy of propofol at 1/4 to 1/5 of the dosage. Ciprofol has the pharmacodynamic characteristics of rapid onset, stable and rapid recovery. Phase III clinical results showed that the incidence of injection pain and respiratory and circulatory depression of ciprofol was lower than that of propofol. Therefore, ciprofol has a good application prospect in the sedation for gastrointestinal endoscopy, especially for overweight and obese patients. We conduct a Multicenter, Randomized, Open-label, Propofol-controlled Study to Evaluate the incidence of hypoxia and severe hypoxia during Gastroenterological Endoscope sedated with CiProfol in Overweight or Obesity patients.

Multicenter, Randomized, Open-label, Propofol-controlled

Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients

The Incidences Of Hypoxia And Severe Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol Compared With Propofol In Overweight Or Obesity Adults Patients, A Multicenter, Randomized, Controlled Trial

hypoxia( 75%≤SpO2≤89% for\<60s);severe hypoxia(SpO2\<75%，or SpO2\<90% for \>60s)

severe hypoxemia(SpO2\<75%，or SpO2\<90% for \>60s)

subclinical respiratory depression（90% ≤SpO2 ≤95% ）

Patients complain pain at the site of injection or tell investigators feeling pain when they were asked before they lose consciousness.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients	NCT05518929	Gastric Ulcer Gastric Cancer Gastrointestina...	Ciprofol Propofol	18 Years - 80 Years	RenJi Hospital
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients	NCT05518929	Gastric Ulcer Gastric Cancer Gastrointestina...	Ciprofol Propofol	18 Years - 80 Years	RenJi Hospital

Spots Global Cancer Trial Database for gastroenterological endoscope