Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Collection of sputum, blood, urine, and a small amount of lung tissue.

comparative genomic hybridization

gene expression microarray analysis

proteomic profiling analysis

biologic sample preservation procedure

Using a brush, superficial cells are removed from the nose.

nasal brushing

Blood draw

Subjects will be asked to provide a urine specimen.

Urine collection

Prior to their bronchoscopy, subjects will be asked for a sputum specimen. This is a collection of mucous that you cough up.

sputum sample

A flexible tube attached to a fluorescent light source will be inserted into the subject's mouth or nose to reach the airway. Samples of the lining of the airway will be taken, as well as bronchial secretions and epithelial cell from brushings of the lining of the airway.

fluorescence bronchoscopy with airway biopsy

A small needle is inserted into the lung to collect tissue. This procedure will only be performed if the patient's physician orders it.

fine needle aspiration of the lung

A small needle is inserted into the patient's lung cavity and a small amount of fluid is collected. This procedure will only be performed if the patient's physician orders it.

thoracentesis

Vanderbilt Ingram Clinical Trials Information Program

VICC Clinical Trials Information Program

Pierre Massion, MD

Research Office

Rena Burns, RN

Fabien Maldonado, MD

RATIONALE: Using samples of blood, urine, sputum, and lung tissue from patients at high risk of cancer for laboratory studies may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at molecular predictors of cancer in patients at high risk of lung cancer.

OBJECTIVES:

* To use fixed lung tissue for histological evaluation and fresh tissue samples for molecular studies to study DNA, RNA, and protein abnormalities in lung preneoplastic and neoplastic lesions.
* To use proteomic techniques, including matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS), to develop a method of diagnosing and staging both pre-invasive and invasive lesions, using less invasive methods.

OUTLINE: Blood, urine, nasal cell, and sputum samples are collected. Lung tissue samples are also collected using fluorescence bronchoscopy and epithelial cell collection.

Samples are studied by genetic and proteomic analyses, including comparative genomic hybridization, expression microarray, and protein profiling.

Blood, urine, nasal cells, sputum, bronchal epithelial cells, airway tissue, and lung tissue

Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer

Molecular Predictors of Lung Cancer Behavior

As a part of the study nasal brushing specimens, sputum, blood, urine, and a small amount of other tissue will be collected during standard of care procedures (bronchial epithelial, trans-thoracic fine needle aspiration (FNA) and thoracentesis as part of patient work up.

Clinical diagnosis is the primary goal of the procedure. All the research specimens are collected after the primary goal of the procedure is met.

Use of proteomic techniques in the laboratory to find a method of diagnosing lung tissue as benign or malignant rather than relying on invasive open-chest surgery for a diagnosis

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer	NCT00898313	Lung Cancer	comparative gen... gene expression... proteomic profi... biologic sample... nasal brushing Blood draw Urine collectio... sputum sample fluorescence br... fine needle asp... thoracentesis	18 Years -	Vanderbilt-Ingram Cancer Center
Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer	NCT00898313	Lung Cancer	comparative gen... gene expression... proteomic profi... biologic sample... nasal brushing Blood draw Urine collectio... sputum sample fluorescence br... fine needle asp... thoracentesis	18 Years -	Vanderbilt-Ingram Cancer Center

Spots Global Cancer Trial Database for gene expression microarray analysis