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Cola

Regional anesthesia and analgesia (either epidural or paravertebral anesthesia).

Subjects randomized to arm 2 will receive general anesthesia followed by opioid analgesia.

Post-operative analgesia will be epidural bupivacaine and fentanyl as well as intravenous morphine.

Regional anesthesia and analgesia

sevoflurane general anesthesia and postoperative opioid analgesia

general anesthesia followed by opioid analgesia

Daniel I Sessler, MD

Andrea Kurz, MD

This study will compare recurrence rates in patients with colorectal cancer who will be randomly assigned to epidural anesthesia/analgesia combined with general anesthesia or to general anesthesia followed by opioid analgesia.

The study population will consist of patients who are scheduled for open laparoscopic or laparoscopic assisted surgery for colon cancer. Patients will randomized into one of two groups. The intervention group will receive combined regional and general anesthesia during surgery. Postoperative pain treatment will be based on regional anesthesia techniques. The Control group will receive general anesthesia during surgery. Postoperative pain treatment will be based primarily on opioids. After surgery, patients will be followed daily during their hospital stay. Patients will be contacted by telephone every 6 months for five years. Quality of life questionnaires will be administered at these follow ups.

Regional Anesthesia in Colon Rectal Surgery

Regional Anesthesia in Patients Undergoing Colon-Rectal Surgery

To determine if recurrence of local/metastatic cancer after open and laparoscopic resection colon cancers is lower in patients randomized to epidural anesthesia \& analgesia than to sevoflurane general anesthesia and postoperative opioid analgesia

To determine if the length of post operative hospitalization is shortened in patients randomized to epidural anesthesia \& analgesia than to sevoflurane general anesthesia and postoperative opioid analgesia.

The Cleveland Clinic

Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Regional Anesthesia in Colon Rectal Surgery	NCT00684229	Colon Cancer	Regional anesth... general anesthe...	18 Years - 85 Years	The Cleveland Clinic
Regional Anesthesia in Colon Rectal Surgery	NCT00684229	Colon Cancer	Regional anesth... general anesthe...	18 Years - 85 Years	The Cleveland Clinic
Regional Anesthesia in Colon Rectal Surgery	NCT00684229	Colon Cancer	Regional anesth... general anesthe...	18 Years - 85 Years	The Cleveland Clinic

Spots Global Cancer Trial Database for general anesthesia followed by opioid analgesia