Symptoms and General Pathology

All Conditions

Diseases and Abnormalities at or Before Birth

Neoplasms

Heart and Blood Diseases

Musculoskeletal Diseases

Nervous System Diseases

Rare Diseases

Syndrome

Congenital Abnormalities

Hemangioendothelioma

Vascular Malformations

Nevus, Pigmented

Klippel-Trenaunay-Weber Syndrome

Nevus

Osteolysis

Osteolysis, Essential

Sturge-Weber Syndrome

Cardiovascular Abnormalities

Hemangioma

Neoplasms, Vascular Tissue

Neoplasms by Histologic Type

Angiomatosis

Vascular Diseases

Bone Diseases

Bone Diseases, Developmental

Bone Resorption

Klippel-Trenaunay Syndrome

Parkes Weber Syndrome

Weber Syndrome

CLOVES Syndrome

Kaposiform Hemangioendothelioma

Lymphangiomatosis

Kaposiform Lymphangiomatosis

Gorham's Disease

All Drugs and Chemicals

Endothelial Growth Factors

Mitogens

Timothy LeCras, PhD

Megan Metcalf

Adrienne Hammill, MD, PhD

The study will use blood (serum and plasma) and tissue obtained from participants undergoing prescribed surgical resection of vascular anomalies of interest proposed in this study. The study will also use blood (serum and plasma) and tissue collected and stored in a tissue bank maintained by the Department of Hematology/Oncology.

While vascular anomalies are rare diseases, they can be life-threatening and devastating to affected children and their families. Advances in diagnosis, monitoring and therapies will be significantly improved if non-invasive biomarkers that are sensitive and specific can be identified. Obtaining a tissue biopsy to help in diagnosis can actually worsen the disease and so identification of specific blood biomarkers is highly desirable. Studies will measure angiogenic factors in serum and plasma samples at baseline and on therapy. Tissue removed during surgical resection or blood removed prior to sclerotherapy will be used to obtain cells and tissue for the assessment of where biomarkers are coming from and to identify disease-causing pathways for new therapeutic targeting.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Identification of Biomarkers for Patients With Vascular Anomalies	NCT03001180	Vascular Anomal... Generalized Lym... Kaposiform Hema... Kaposiform Lymp... Gorham-Stout Di... Klippel Trenaun... Congenital Lipo...		1 Day -	Children's Hospital Medical Center, Cincinnati
Identification of Biomarkers for Patients With Vascular Anomalies	NCT03001180	Vascular Anomal... Generalized Lym... Kaposiform Hema... Kaposiform Lymp... Gorham-Stout Di... Klippel Trenaun... Congenital Lipo...		1 Day -	Children's Hospital Medical Center, Cincinnati

Spots Global Cancer Trial Database for generalized lymphatic anomaly