Infections

All Conditions

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Neoplasms

Communicable Diseases

Papillomavirus Infections

Papilloma

Virus Diseases

Disease Attributes

Neoplasms, Squamous Cell

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Sexually Transmitted Diseases

Sexually Transmitted Diseases, Viral

DNA Virus Infections

Tumor Virus Infections

Genital Diseases

Urogenital Diseases

Anti-Infective Agents

All Drugs and Chemicals

Herbal and Botanical

Antiviral Agents

Olive

Topical spray one-time administration 2 puffs of 100µl

Topical spray one-time application 2 puffs of 100µl

one time (2 puffs) topical application of 100µl AV2-DM antiviral spray( containing 50% AV2-DM and 50% olive oil)on the cervix

topical application cervical spray

one time (2 puffs) topical spray of 100 µl (90% olive oil and 10% d-limonene) on the cervix

topical spray on the cervix

cervical swab with Cervex-Brush-Combi at T0

cervical swab with Cervex-Brush-Combi at T1

This study aims to prove that, by a one-time topical spray on the cervix, AV2-DM is an effective antiviral in reducing on short term (3 months) the human papillomavirus (HPV) infection.

* Primary endpoint: significant drop in viral load AV2-DM versus placebo
* Secondary endpoint:the number of patients with adverse events

AV2 Antiviral Spray Versus Placebo in Human Papillomavirus Cervix Infections

Single Center, Placebo Controlled, Double-Blind Study to the Treatment of HPV Infected Cervix With AV2 Antiviral Spray and Assessment of Viral Load

Cesa Projects International

Uterine Cervical Neoplasms

Emergencies

Vaccines

Immunologic Factors

0.5ml IM for three doses, Second and third dose to be given at 2 months and 6 months

Gardasil

Alicia Devine, MD

LaBarbara Edlow, RN

Alicia S Devine, MD, JD

In this pilot study, we intend to demonstrate that a great portion of women at high risk (inadequate screening, HPV 16/18 and/or cytology) are presenting to the ED, cytology/ HPV testing via ThinPrep®Pap testTM and surveillance. We intend to provide improved access to healthcare and monitoring through administration of vaccine to eligible patients and 1 year follow up for patients involved in this study.

Females meeting inclusion/exclusion criteria participating in the study (n=100) that have not had a cytology test in 2 or more years will be offered the Thin Prep® cytology test. This study will allow surveillance of disease through cytology and HPV DNA testing via collection of data using Thin Prep® cytology with reflex HPV DNA testing according to established guidelines as described below.

Provide improved access to healthcare and monitoring through administration of vaccine for eligible females as established by guidelines. Patients will receive first vaccine in the ED and will have arranged follow up for administration of the 2 month and 6 month series of the HPV vaccination. Through data collection, we intend to determine if there is a need for vaccination and determine if patients are likely to follow up..

A Model for Implementation of Cervical Cancer Screening and HPV Vaccination the Emergency Department: a Pilot Study

A Model for the Implementation of the Cervical Cancer Screening and HPV Vaccination in the Emergency Department: a Pilot Study.

Merck Sharp & Dohme LLC

Eastern Virginia Medical School

Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
AV2 Antiviral Spray Versus Placebo in Human Papillomavirus Cervix Infections	NCT01654822	Genital Human P...	topical applica... topical spray o... cervical swab w... cervical swab w... cervical swab w... cervical swab w...	25 Years - 40 Years	Cesa Projects International
A Model for Implementation of Cervical Cancer Screening and HPV Vaccination the Emergency Department: a Pilot Study	NCT01133509	Genital Human P...	Gardasil	18 Years - 26 Years	Eastern Virginia Medical School
AV2 Antiviral Spray Versus Placebo in Human Papillomavirus Cervix Infections	NCT01654822	Genital Human P...	topical applica... topical spray o... cervical swab w... cervical swab w... cervical swab w... cervical swab w...	25 Years - 40 Years	Cesa Projects International

Spots Global Cancer Trial Database for genital human papilloma virus infection