Symptoms and General Pathology

All Conditions

Neoplasms

Digestive System Diseases

Behaviors and Mental Disorders

Postoperative Complications

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Quality of Life

Nutrition Risk Screening 2002 (NRS-2002)

Global Leadership Initiative on Malnutrition (GLIM)

The cross section of the third lumbar vertebrae in the CT scan images of the patients will be analyzed for assessment of body composition parameters including skeletal muscle area (SMA), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT)

Measurement of body composition with computed tomography (CT)

The Dietary Inflammatory Index (DII) is a scoring algorithm that indicates the inflammatory potential of the diet.

Dietary inflammatory index (DII)

European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30)

European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Colorectal Cancer 29 (EORTC-QLQ-CR29)

Prognostic Nutritional Index is diagnostic test based on serum albumin level and total lymphocyte count

Prognostic Nutritional Index (PNI)

The neutrophil-to-lymphocyte ratio (NLR) is calculated as the simple ratio between neutrophil and lymphocyte counts.

Neutrophil-Lymphocyte Ratio (NLR)

Tuba N Yildiz Kopuz

Mehmet Fisunoglu

The aim of this study was to evaluate the effect of preoperative nutritional status, dietary inflammatory index, and systemic inflammatory response on postoperative outcomes. The study will include 120 colorectal cancer patients who are scheduled for surgical treatment.

A questionnaire form containing general information, dietary habits, and food consumption records will be applied by the researcher in the preoperative period to the patients who volunteered to participate in the study. Body composition will be taken by bioelectrical impedance analysis method. Hand grip strength will be taken with a digital hand dynamometer. The nutritional status of patients will be assessed using the criteria of the Nutritional Risk Screening 2002 (NRS-2002) and the Global Leadership Initiative on Malnutrition (GLIM). For body composition analysis, computed tomography images, known as the gold standard, will be used in cancer patients. Computed tomography images of the patients will be obtained from hospital records at L3 lumbar vertebra level. The software program ImageJ developed by the US National Institute of Health will be used to calculate the visceral fat area (cm2), subcutaneous fat area (cm2), and skeletal muscle area (cm2) from the recorded images.

Preoperative biochemical parameters will be obtained from hospital records. The systemic inflammatory response will be determined by the Prognostic Nutritional Index, Neutrophil Lymphocyte Ratio, and Delta Neutrophil Index. The inflammatory load of the diet will be calculated using the Dietary Inflammatory Index. The quality of life of patients will be assessed using cancer-specific scales developed by the European Organisation for Research and Treatment of Cancer (EORTC) during the preoperative and postoperative periods. These scales are EORTC-QLQ-C30 for general quality of life and EORTC-QLQ-CR29 for colorectal cancer-specific quality of life.

Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer

The Effect of Preoperative Nutritional Status, Dietary Inflammatory Index and Systemic Inflammatory Response on Postoperative Outcomes in Colorectal Cancer.

Complications graded by Clavien-Dindo Complication Classification System

Quality of life will be evaluated by European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30).All of the scales and single-item measures range in score from 0 to 100. A high scale score represents a higher response level.

European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Colorectal Cancer 29 (EORTC-QLQ-CR29) is a supplementary questionnaire module to be employed in conjunction with the Quality of Life Questionnaire Core 30 (QLQ-C30). All of the scales and single-item measures range in score from 0 to 100. A high score for the functional scale and functional single-items represents a high level of functioning, whereas a high score for the symptom scales and symptom single-items represents a high level of symptomatology or problem.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer	NCT06016829	Colorectal Canc...	Nutrition Risk ... Global Leadersh... Measurement of ... Dietary inflamm... European Organi... European Organi... Prognostic Nutr... Neutrophil-Lymp...	18 Years -	Hacettepe University
Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer	NCT06016829	Colorectal Canc...	Nutrition Risk ... Global Leadersh... Measurement of ... Dietary inflamm... European Organi... European Organi... Prognostic Nutr... Neutrophil-Lymp...	18 Years -	Hacettepe University
Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer	NCT06016829	Colorectal Canc...	Nutrition Risk ... Global Leadersh... Measurement of ... Dietary inflamm... European Organi... European Organi... Prognostic Nutr... Neutrophil-Lymp...	18 Years -	Hacettepe University

Spots Global Cancer Trial Database for global leadership initiative on malnutrition (glim)