Nutritional and Metabolic Diseases

Symptoms and General Pathology

All Conditions

Neoplasms

Blood and Lymph Conditions

Immune System Diseases

Rare Diseases

Obesity

Leukemia

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Leukemia, Lymphoid

Lymphoma

Pediatric Obesity

Neoplasms by Histologic Type

Hematologic Diseases

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Overweight

Overnutrition

Nutrition Disorders

Body Weight

Acute Lymphoblastic Leukemia

Lymphoblastic Lymphoma

Acute Graft Versus Host Disease

Childhood Acute Lymphoblastic Leukemia

Lymphosarcoma

Following a low glycemic index diet verses a standard american diet.

The nutritional intervention is theory-based and will provide nutritional education and counseling to children and their families. Nutritional counseling will be provided by the institutional designate and will focus on increasing patients' understanding of the benefits of a low GI diet, increase knowledge of low GI diet, overcoming barriers, and establishing expectations of the diet.

Low Glycemic Index Diet

Elena Ladas, PhD

The study aims to determine the feasibility of a 6-month low glycemic dietary intervention in children and adolescents undergoing treatment for acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy with survival exceeding 90%. However, treatment-related toxicity remains a clinical challenge during and after treatment. Evidence-based, nutritional interventions may minimize the development of nutrition-related toxicities, such as bone morbidities, hypertriglyceridemia, and obesity. To date, no effective interventions are available to prevent nutrition-related morbidities in children with ALL. Clinical studies evaluating the glycemic indices in other pediatric conditions have been encouraging. It is plausible that reducing the glycemic indices of diets during cancer treatment may have a profound clinical effect in this vulnerable pediatric population. Prior to the design and implementation of randomized, controlled trials, epidemiological data describing the Glycemic Index (GI) and Glycemic Load (GL) and the association with clinically important outcomes is needed. Additionally, the feasibility of a dietary intervention must also be explored within the setting of pediatric cancer. This study aims to determine the feasibility, measured by compliance to a low-GI diet, of a 6-month low glycemic dietary intervention in children and adolescents undergoing treatment for ALL. The proposed work will be used for the design and implementation of a multi-center nutritional intervention aimed at improving dietary intake during treatment and its effect on clinically important outcomes. Importantly, the information will be used to drive the formation of evidence-based nutritional guidelines for children with cancer, which will expand into the emerging field of individualized medicine for patients with cancer.

Low GI Diet in Children and Adolescents With ALL

Implementing a Low Glycemic Diet in Children and Adolescents Undergoing Treatment for Acute Lymphoblastic Leukemia

Feasibility will be measured by compliance to a low glycemic index diet, which will be measured via 24 dietary recall, using the Automated Self-Administered 24-Hour Dietary Assessment Tool. A dietary recall will be taken at 7 timepoints from diagnosis to end of treatment; each recall will be defined categorically as high compliance (GI score \<55), moderate compliance (GI score 56-69) and low compliance (GI score \>70). Change in glycemic index score will show compliance.

American Cancer Society, Inc.

Gabrielle's Angel Foundation

Columbia University

Assistant Professor of Nutrition in Pediatrics and in the Institute of Human Nutrition

Hypoglycemic Agents

All Drugs and Chemicals

Insulin

Insulin, Globin Zinc

consume both high and low glycemic load diets for 28 days each

Low Glycemic Load Diet

High Glycemic Load Diet

Marian Neuhouser, RD, PhD

This study is designed to investigate associations of low- and high-glycemic load diets with biomarkers of hyperglycemia, hyperinsulinemia and inflammation, potential biomarkers for cancer risk.

This is a randomized, crossover feeding study conducted in normal weight and overweight individuals. Participants will be given all their food to eat and drink (except water) for two 28-day feeding periods (a total of 56 days). The diets will be carefully controlled and energy intake will be regulated to maintain weight stability for each participant. The two feeding periods will be separated by a 28 day "washout" period when participants will eat their own food. Dinner will be eaten at the Hutchinson Center Monday through Friday. Each evening, breakfast, lunch and snacks will be brought home for the next day. On Friday evenings all the food will be taken home for the weekend.

Samples of blood will be collected after an overnight fast at the beginning and the end of each feeding period. All urine will be collected for 24 hours at the end of each feeding period. A number of questionnaires will also be completed during each diet period. A small stool sample will be collected in your own home, before the first feeding period, and once during each feeding period. The stool sample collection is optional. One can decide not to provide a stool sample and still participate in the study.

Carbohydrates and Related Biomarkers

A Feeding Study to Examine the Effect of Glycemic Load and Obesity on Cancer Biomarkers

National Cancer Institute (NCI)

Fred Hutchinson Cancer Center

Marian Neuhouser

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Low GI Diet in Children and Adolescents With ALL	NCT03157323	Acute Lymphobla... Obesity, Pediat...	Low Glycemic In...	5 Years - 21 Years	Columbia University
Carbohydrates and Related Biomarkers	NCT00622661	Healthy Overweight	Low Glycemic Lo... High Glycemic L...	18 Years - 45 Years	Fred Hutchinson Cancer Center
Carbohydrates and Related Biomarkers	NCT00622661	Healthy Overweight	Low Glycemic Lo... High Glycemic L...	18 Years - 45 Years	Fred Hutchinson Cancer Center
Low GI Diet in Children and Adolescents With ALL	NCT03157323	Acute Lymphobla... Obesity, Pediat...	Low Glycemic In...	5 Years - 21 Years	Columbia University

Spots Global Cancer Trial Database for glycemic index