Nutritional and Metabolic Diseases

Symptoms and General Pathology

All Conditions

Overweight

Obesity

Overnutrition

Nutrition Disorders

Body Weight

Hypoglycemic Agents

All Drugs and Chemicals

Insulin

Insulin, Globin Zinc

consume both high and low glycemic load diets for 28 days each

Low Glycemic Load Diet

High Glycemic Load Diet

Marian Neuhouser, RD, PhD

This study is designed to investigate associations of low- and high-glycemic load diets with biomarkers of hyperglycemia, hyperinsulinemia and inflammation, potential biomarkers for cancer risk.

This is a randomized, crossover feeding study conducted in normal weight and overweight individuals. Participants will be given all their food to eat and drink (except water) for two 28-day feeding periods (a total of 56 days). The diets will be carefully controlled and energy intake will be regulated to maintain weight stability for each participant. The two feeding periods will be separated by a 28 day "washout" period when participants will eat their own food. Dinner will be eaten at the Hutchinson Center Monday through Friday. Each evening, breakfast, lunch and snacks will be brought home for the next day. On Friday evenings all the food will be taken home for the weekend.

Samples of blood will be collected after an overnight fast at the beginning and the end of each feeding period. All urine will be collected for 24 hours at the end of each feeding period. A number of questionnaires will also be completed during each diet period. A small stool sample will be collected in your own home, before the first feeding period, and once during each feeding period. The stool sample collection is optional. One can decide not to provide a stool sample and still participate in the study.

Carbohydrates and Related Biomarkers

A Feeding Study to Examine the Effect of Glycemic Load and Obesity on Cancer Biomarkers

National Cancer Institute (NCI)

Fred Hutchinson Cancer Center

Marian Neuhouser

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Carbohydrates and Related Biomarkers	NCT00622661	Healthy Overweight	Low Glycemic Lo... High Glycemic L...	18 Years - 45 Years	Fred Hutchinson Cancer Center
Carbohydrates and Related Biomarkers	NCT00622661	Healthy Overweight	Low Glycemic Lo... High Glycemic L...	18 Years - 45 Years	Fred Hutchinson Cancer Center

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