Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Symptoms and General Pathology

Urinary Bladder Neoplasms

Hematuria

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urinary Bladder Diseases

Urologic Diseases

Male Urogenital Diseases

Group

John Kelly, FRCS (urol)

DETECT I is a prospective multicentre observational diagnostic study to assess the performance of the UroMark assay to rule out bladder cancer in patients with haematuria. The study will recruit consecutive patients attending haematuria clinics as well as patients referred to urology outpatient clinics for investigation of haematuria. Consenting patients will be provided with a urine sample collection kit and asked to provide a urine sample. An additional urine sample for control assay testing will be provided after the clinic attendance.

Transitional cell carcinoma (TCC) of the urinary bladder is responsible for \>12,000 new cases of cancer and \>5,000 deaths per year in England and Wales. Most bladder cancers are non-muscle invasive bladder cancer (NMIBC) and do not invade deeply at presentation, but 80% of tumours recur within 3 years. For muscle invasive bladder cancer (MIBC), the 5 year survival is around 50%. Cystoscopy is the standard test for detection of bladder cancer along with imaging to assess the upper tracts and the common presenting symptom is haematuria. Cystoscopy is an invasive procedure and results in urinary infection in up to 5% of cases. Cystoscopy is performed under local anaesthetic and patients are required to attend hospital clinics for the test. About one in 10 patients who are investigated for haematuria will be found to have bladder cancer. Frequently, patients are not referred for investigation of haematuria at the time of first presentation and there is a delay in diagnosis of the disease. The early detection of bladder cancer by means of a non-invasive tumour marker test would impact on the management of the disease. There is an unmet need for a simple, non-invasive, highly sensitive and specific method for detecting bladder cancer.

This study will determine the accuracy of UroMark a high-throughput multiplex PCR test to detect bladder cancer in DNA from urine. The study will address the unmet clinical need to improve detection of bladder cancer. The rationale for the trial is based on proof of concept studies which provide compelling evidence that a panel of methylation markers can be applied to detect bladder cancer with high sensitivity and specificity. It will be also be possible to collect and store fractions of urine for assessment of other DNA related biomarkers as well as non-DNA assays for example cellular proteins, soluble biomarkers in urine supernatant and RNA transcripts in sediment cells. In this study we will compare the UroMark assay with established assays including urinary cytology, FISH as well as developing assays such as MCM5. In this proposal excess urine will be stored for these studies.

Urine will be collected for analysis using UroMark assay.

Detecting Bladder Cancer Using the UroMark Test.

A Prospective Observational Study to Determine the Negative Predictive Value of UroMark to Rule Out the Presence of Bladder Cancer in Patients With Haematuria.

University College, London

Nervous System Diseases

Cancer Pain

Pain

Neurologic Manifestations

Group acupuncture sessions take place in a multipurpose room, with 3-6 participants, each session lasts 30-45 minutes, occurring twice-weekly, over the course of six weeks, for a total of twelve treatments. The acupuncture was administered by a Naturopathic Doctor.

Individual acupuncture sessions take place in a multipurpose room, privately each session lasts 30-45 minutes, occurring twice-weekly, over the course of six weeks, for a total of twelve treatments. The acupuncture was administered by a Naturopathic Doctor.

Traditional Chinese Medicine (TCM) Acupuncture

Acupuncture

Linda E Carlson, PhD

Typically, in North America, acupuncture is performed on an individual basis. However, community acupuncture, also known as group acupuncture, is an emerging method of treating patients. Cancer patients, post-treatments were given acupuncture treatments to help alleviate pain, in a two-arm randomized trial.

Typically, in North America, acupuncture is performed on an individual basis. However, community acupuncture, also known as group acupuncture, is an emerging method of treating patients. Although the practice can vary, community acupuncture is performed in a group setting, typically with reclining chairs dispersed around a large room, and one practitioner treating up to six people per session.

The outcomes of this this randomized controlled trial will allow the researchers to assess whether group acupuncture is a viable treatment option for people with cancer who are suffering from pain, especially those who are either resistant to or looking to avoid the side effects of opioids.

Objectives Examine the efficacy of community acupuncture for alleviating cancer pain, fatigue, sleep disturbances and distress when compared to individual acupuncture.

Evaluate the cost-effectiveness of community acupuncture compared to individual acupuncture.

Group Versus Individual Acupuncture for Cancer Pain

A Non-Inferiority Randomized Controlled Trial Comparing Community (Group) Acupuncture to Individual Acupuncture to Alleviate Cancer Pain

The Brief Pain Inventory-Short Form (BPISF) is a widely used self-report measure, originally developed for cancer pain, which measures both pain severity and pain interference

The Profile of Mood States-Short Form (POMS-SF) is a validated measure of psychological distress, which calculates Total Mood Disturbance (TMD) using six subscales: fatigue, vigor, tension, depression, anger and confusion (Shacham, 1983). The 37-item questionnaire asks patients to rate how various adjectives relate to how they have felt in the past week, on a Likert scale from zero (not at all) to four (extremely).

The Pittsburg Sleep Quality Index (PSQI) is 19-item questionnaire that measures quality of sleep and sleep disturbances

The Functional Assessment of Cancer Therapy-General (FACT-G) is a 20-item questionnaire that measures health-related quality of life (HRQOL) within the cancer population. The questionnaire contains four subscales: physical, social/family, emotional and functional well-being.

The Functional Assessment of Cancer Therapy-Fatigue (FACT-F) comprised of the FACT-G, plus an additional 13 questions related to fatigue

The Inventory of Socially Supportive Behaviours (ISSB) Short Form is an 18-item questionnaire designed to measure social support, which asks participants to indicate the number of times they have experienced particular behaviours in the past month

The Edmonton Symptom Assessment Scale (ESAS) is a simple screening measure that can be used to assess various physical and psychological symptoms, originally designed for palliative care patients

The pain visual analog scale (VAS) consists of a 10 centimetre line on a slip of white paper, with the indicators "no pain at all" on the far-left end, and "worst pain imaginable" on the far-right end

This utility scoring instrument is intended to provide an overall quality of life evaluation with a scale from 1 (perfect health) to 0 (death) and allows for the calculation of quality adjusted life years (QALYs)

University of Calgary

Professor, Department of Oncology

Skin and Connective Tissue Diseases

Breast Neoplasms

Bollywood dance is a routine that doubles as both physical and mental exercise.

Bollywood Dance

Colleen Maher, OTD

The purpose of this mixed methods study is to evaluate the effects an 8-week group dance intervention can have on body image and posture in breast cancer survivors.

The purpose of this mixed methods study is to evaluate the effects of an 8-week group dance intervention on body image and posture in breast cancer survivors.

Program Description: An 8-week dance intervention was held at a local cancer support center in the greater Philadelphia region. The study ran for 8 weeks, and each class was held once a week for 60 minutes. Every class consisted of a 5-10 minute stretching warm up leading to approximately 50 minutes of teaching light choreography set to Bollywood music.

Methods: This was a mixed methods study utilizing two quantitative assessments and a qualitative portion comprising of initial and exit surveys. Breast cancer survivors were recruited from a local non-profit cancer support community in the greater Philadelphia region. A sample of twelve women (n=12) fulfilled inclusion criteria of being diagnosed with and treated for breast cancer. Dropout rate was low, and only 1 person fit this criteria. Informed consent was sought after and obtained through the University of the Sciences in Philadelphia Institutional Review Board.

Procedure: Group dance intervention program lasted for 8 weeks in total with no control group. All twelve subjects participated in 60-minute dance sessions, once a week for 8 weeks. At the beginning and termination of this 8 week dance intervention, all subjects took a series of assessments including the Body Image Scale (BIS), postural assessment using the plumbline method, and initial and exit open-ended surveys to assess any additional benefits of the program.

Analysis: Data review was completed through Microsoft Excel and SOFA Statistics (version 1.4.6), a free statistical analysis program (available online for download at www.sofastatistics.com). Means and modes were found in demographics using Excel. Qualitative data was explored initially through reading surveys and noting repetitive points. Survey data was coded by highlighting and labeling segments of common responses to survey questions. To ensure findings were consistent, an independent reviewer was employed to verify coded data. Codes were later organized according to similarity to develop common themes. Themes found from initial and exit surveys were studied closer using a comparative analysis, to look for connecting themes from initial and exit surveys.

Physical and Emotional Benefits of Group Dance Intervention for Breast Cancer Survivors

BIS is a 10-item likert scale questionnaire developed to assess body image. In a study by Hopwood et al. (2001), the BIS showed high reliability (Cronbach's alpha=0.93) and good clinical and discriminant validity.

Photographs were taken from a lateral view to assess shoulder posture. After palpating for the acromion joint, a tape marker was placed on the mid-acromion process. Participants were asked to stand with feet hip distance apart and look straight ahead. A full body picture was then taken from the lateral profile view. Pages for Apple, a computer software available through Mac (versions 10.11.3 and higher) was used to place a digital plumbline marker, which was perpendicular to the lateral malleolus on each photo. A second digital line was placed perpendicular from the mid-acromion process to the plumbline marker. The horizontal distance from the mid-acromion process to the plumbline marker was measured (inches) for each photo.

Initial and exit open-ended surveys to assess any additional benefits of the program

Spots Global Cancer Trial Database for group

Every month we try and update this database with for group cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Detecting Bladder Cancer Using the UroMark Test.	NCT02676180	Bladder Cancer	Group	18 Years -	University College, London
Group Versus Individual Acupuncture for Cancer Pain	NCT03641222	Cancer Pain	Acupuncture	18 Years -	University of Calgary
Group Versus Individual Acupuncture for Cancer Pain	NCT03641222	Cancer Pain	Acupuncture	18 Years -	University of Calgary
Physical and Emotional Benefits of Group Dance Intervention for Breast Cancer Survivors	NCT02793076	Cancer	Bollywood Dance	18 Years -	University of the Sciences in Philadelphia
Group Versus Individual Acupuncture for Cancer Pain	NCT03641222	Cancer Pain	Acupuncture	18 Years -	University of Calgary
Detecting Bladder Cancer Using the UroMark Test.	NCT02676180	Bladder Cancer	Group	18 Years -	University College, London

Spots Global Cancer Trial Database for group

Every month we try and update this database with for group cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for group cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.