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Ham : 160g/d during 4 days calcium : 1000mg/d during 4 days

Ham + calcium

Ham : 160g/d during 4 days Vitamin E : 80 mg/d during 4 days

Ham + vitamin E

Noël Cano, MD, PhD

Fabrice Pierre, PhD

Colorectal cancer kills forty five people in France every day. Epidemiological studies suggest that two cases out of three could be prevented and show that processed meat intake is a consistent risk factor. The aim of this study is to understand how meat promotes cancer, to find protective strategies, and to make compelling dietary recommendations.

18 healthy volunteers will be randomized and will start the study. The study will last 4 weeks for each subject. The first week will be a week of adaptation (or run-in period) to the diet which they will have to follow for the duration of study. During this period, they will collect 2 samples of stools and urine. Then subjects will alternate 4 days of diet either with ham, or with ham and calcium, or with ham enriched with vitamin E. At least, 3 days will separate every period (wash-out) of nutritional intervention. Urines and stools will be collected last 3 days of every interventional period and also last day of every wash out period.

Processed Meat and Colon Carcinogenesis

Effect of Processed Meat on Colorectal Carcinogenesis. Study of Mechanisms. Choice of Preventive Strategies

Centre de Recherche en Nutrition Humaine d'Auvergne

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Clinical research Assistant

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Processed Meat and Colon Carcinogenesis	NCT00994526	Colorectal Canc...	Ham Ham + calcium Ham + vitamin E	40 Years - 75 Years	Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Processed Meat and Colon Carcinogenesis	NCT00994526	Colorectal Canc...	Ham Ham + calcium Ham + vitamin E	40 Years - 75 Years	Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

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