Neoplasms

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Ear, Nose, and Throat Diseases

Carcinoma

Carcinoma, Squamous Cell

Head and Neck Neoplasms

Laryngeal Neoplasms

Squamous Cell Carcinoma of Head and Neck

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Otorhinolaryngologic Neoplasms

Laryngeal Diseases

Respiratory Tract Diseases

Respiratory Tract Neoplasms

Otorhinolaryngologic Diseases

PART I: Patients undergo PAI before the start of chemoradiation therapy, weekly during 7 weeks of chemoradiation, and again 3-4 months after completion of chemoradiation therapy.

PART II (CANCER-FREE WITH XEROSTOMIA): Patients undergo PAI at baseline, up to twice during acupuncture-like transcutaneous nerve stimulation (ALTENS) therapy, once after ALTENS, and at 3-6 months follow up.

Photoacoustic Imaging

Transcutaneous Acupoint Electrical Stimulation

Anurag K Singh

This trial studies how well photoacoustic imaging works in measuring tumors and normal tissue in patients with head and neck cancer. Photoacoustic imaging (PAI) is a low-risk imaging method that provides information about the oxygenation of tissues using a combination of light and ultrasound techniques. This study may help doctors determine if PAI is correlated with clinical responses of both tumor (for example: shrinking, swelling or disappearing) and normal tissues (for example: skin redness, dry mouth, appearance of sores, healing of skin or mucosa). If there is a correlation with clinical responses, then doctors may develop PAI as method for measuring response to earlier treatment.

PRIMARY OBJECTIVE:

I. Define the feasibility of the current photoacoustic imaging (PAI) technology in head and neck (H\&N) cancer patients.

SECONDARY OBJECTIVE:

I. Define the utility of the current PAI in H\&N cancer patients.

OUTLINE:

PART I: Patients undergo PAI before the start of chemoradiation therapy, weekly during 7 weeks of chemoradiation, and again 3-4 months after completion of chemoradiation therapy.

PART II (CANCER-FREE WITH XEROSTOMIA): Patients undergo PAI at baseline, up to twice during acupuncture-like transcutaneous nerve stimulation (ALTENS) therapy, once after ALTENS, and at 3-6 months follow up.

Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer

A Pilot Study of Photoacoustic Imaging (PAI) in H&Amp;N Cancer Patients

Feasibility rate is defined as the proportion of evaluable patients who have at least 3 imaging sessions that produce a usable image.

Descriptive statistics (means, medium) will be used to summarize percent of SO2

Compare hemoglobin measurements between baseline until end of study

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer	NCT04110249	Head and Neck C... Head and Neck L... Head and Neck S... Laryngeal Neopl... Radiation Thera...	Photoacoustic I... Transcutaneous ...	18 Years -	Roswell Park Cancer Institute
Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer	NCT04110249	Head and Neck C... Head and Neck L... Head and Neck S... Laryngeal Neopl... Radiation Thera...	Photoacoustic I... Transcutaneous ...	18 Years -	Roswell Park Cancer Institute

Spots Global Cancer Trial Database for head and neck lymph node