Neoplasms

All Conditions

Symptoms and General Pathology

Carcinoma

Carcinoma, Squamous Cell

Recurrence

Squamous Cell Carcinoma of Head and Neck

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Squamous Cell

Head and Neck Neoplasms

Antineoplastic Agents

All Drugs and Chemicals

Pembrolizumab

Docetaxel

Cetuximab

Magrolimab

Tubulin Modulators

Antimitotic Agents

Antineoplastic Agents, Immunological

Immune Checkpoint Inhibitors

Participants will receive magrolimab and cetuximab along with pembrolizumab.

Participants will receive magrolimab and cetuximab along with docetaxel.

cetuximab

Renata Ferrarotto, M D

To learn if magrolimab, along with a combination of commercially-available drugs (cetuximab, pembrolizumab, and docetaxel) can help to control HNSCC in combination with other drugs. The safety of magrolimab will also be studied.

Primary Objectives:

-Objective response rate (ORR) per RECIST v1.1

Secondary Objectives:

* Adverse events rates per CTCAE V5.0 (appendix)
* Duration of response (DOR)
* Progression free survival (PFS) per RECIST v1.1
* Overall survival (OS) per RECIST v1.1

Exploratory Objectives:

-Assessment of blood and tissue-based biomarkers predictive of response to therapy

Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma

Gilead Sciences

M.D. Anderson Cancer Center

Spots Global Cancer Trial Database for head neck

Every month we try and update this database with for head neck cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for head neck

Every month we try and update this database with for head neck cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for head neck cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.