Infections

All Conditions

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Communicable Diseases

Papillomavirus Infections

Sexually Transmitted Diseases

Sexually Transmitted Diseases, Viral

Virus Diseases

DNA Virus Infections

Tumor Virus Infections

Genital Diseases

Urogenital Diseases

Disease Attributes

All Drugs and Chemicals

Vaccines

A 2-hour education session with multicomponent interventions including education sessions with small group dialogues with a registered nurse and trained healthcare and lay volunteers and educational computer games

MDL-SHPVP

A 30-minute education video (DVD) on HPV, cervical cancer and the HPV vaccine that is designed to enhance HPV vaccine acceptance

30-minute educational video

Pak Chun Janita Chau, PhD

The MDL-SHPVP will be developed and a clustered randomised controlled trial will be conducted to evaluate the effects of the MDL-SHPVP and to examine whether the effect of the MDL-SHPVP on the rate of HPV vaccine uptake 1 year after intervention is mediated by parents'/guardians' and female adolescents' HPV knowledge, attitudes and beliefs, adolescents' intention to receive HPV vaccination and vaccine acceptance among their parents/guardians.

2520 adolescents and their parents or guardians from 18 local secondary day schools will be recruited. Multicomponent interventions will be offered to the intervention schools. To build and strengthen the community capacity in health promotion, a team of volunteers will be established to raise awareness of HPV, cervical cancer and HPV vaccine.

Data will be collected at baseline, 1 month and 1 year after intervention. The mixed-effects model will be used to compare the differential changes for each of the primary and secondary outcomes across time between the two groups.

The project is expected to instil a more accurate understanding of HPV and HPV vaccination and support the decision to undergo vaccination.

The HPV vaccination mainly targets at female in Hong Kong, with the inclusion in Hong Kong Child Immunisation Programme to eligible female students at Primary 5 and 6 from 2019/2020 school year.

HPV Vaccination Health-promotion Programme on Vaccine Acceptance and Uptake Among Female Adolescents

Effects of a Multidisciplinary Team-led School-based Human Papillomavirus Vaccination Health-promotion Programme (MDL-SHPVP) on Improving Vaccine Acceptance and Uptake Among Female Adolescents: A Cluster Randomised Controlled Trial

Self report uptake of the HPV vaccine by the female adolescents in the past 12 months.

A 10-point Likert scale will be used to measure the intention indicates "Definitely". 1 indicates "Definitely not" and 10 indicates "Definitely". Higher value means higher intention.

Precaution Adoption Process Model will be used to measure the vaccine acceptance.

HPV General and HPV Vaccine Knowledge Scale will be used to measure the knowledge.1 point will be given to each correct answer and 0 points will be given to each incorrect or "Don't know" answer. Higher scores mean more HPV knowledge.

Carolina HPV Immunisation Attitudes and Beliefs Scale will be used to measure the attitudes and belief.

An 11-point Likert scale will be used, with 0, 5, 7 and 10 indicate "strongly disagree," "somewhat disagree," "somewhat agree" and "strongly agree" respectively, or indicate "extremely ineffective, "somewhat ineffective," "somewhat effective" and "extremely effective" respectively. Higher values mean stronger agreement with the statement and less agreement with or endorsement of HPV vaccination. Five items will be reverse-coded.

Carolina HPV Immunisation Attitudes and Beliefs Scale will be used to measure the attitudes and belief.

A 4-point Likert scale will be used. 1,2,3 and 4 indicate "strongly disagree," "somewhat disagree," somewhat agree," and "strongly agree" respectively. Higher values indicate stronger agreement with the statement.

Chinese University of Hong Kong

Professor

General public to be approached to answer this survey via GPs, charities and exhibitions such as Great Exhibition Road Festival.

Members of the public will be asked to complete a survey that collects information on individuals perception of health and disease and their views on breath testing.

Survey

Pallavi Huma Arya

Munir Tarazi

George Hanna, PhD

A brief survey for the public to determine interest in health surveillance and disease detection

There are numerous barriers and favourable conditions that affect the acceptability of a screening test for cancer. Such factors have been investigated in the context of some of the current screening programs. Through this survey the investigators want to increase researcher awareness of these factors with the hope that this information will aid policy makers and guide future research.

There has been widening public interest in general health-surveillance in addition to disease detection. Breath testing has the potential to be a one-for-all non-invasive test to detect health domains. Through this survey, the investigators wish to understand public opinions about breath testing for health.

This survey consists of questions aiming to gather views on non-invasive testing for health and disease.

Public Survey on Breath Testing for Health and Disease

Proportion of people that find breath testing an acceptable means to determine health or disease

Imperial College London

Digestive System Diseases

Syndrome

Low Anterior Resection Syndrome

Gastrointestinal Diseases

Intestinal Diseases

Rectal Diseases

Colonic Diseases

Postoperative Complications

Participants will have access to an interactive online peer support app developed by the research team.

Participants will only have access to the educational booklet on LARS developed by the colorectal research team.

The app contains LARS information, bowel function diaries, and online platform with trained peer support mentor

Interactive online informational and peer support app

Jeongyoon Moon, MD

Sarah Sabboobeh, MSc

Jenny Moon, MD

Willis Cao

Selina Schmocker

Taariq Shaikh

Jenny Moon

After surgery for rectal cancer, many people undergo changes in bowel habits, which may include the need to empty their bowels more often, accidental leakage of stool or gas, the sudden urge to go to the bathroom, and more. The term "Low Anterior Resection Syndrome" or LARS is used to describe these symptoms. LARS has a negative impact on one's quality of life, and can lead to frustration, as there is no single intervention that has proven to be effective for LARS, and each patient has to undergo trial and error to find one's solution. As people struggle with LARS, they describe feeling hopeless and isolated. Peer support is a supportive relationship between individuals who share common experiences or face similar challenges. The goal of our study is to evaluate whether use of an online peer support application with trained mentors who themselves have lived or are living with LARS will empower patients to better manage their LARS symptoms and improve their quality of life.

Restorative proctectomy is increasingly being performed for rectal cancer, allowing patients to avoid permanent colostomy. Low Anterior Resection Syndrome (LARS) refers to a constellation of bowel symptoms including frequency, urgency, incontinence, and clustering of bowel movements, that can affect up to 70 to 90% of patients following restorative proctectomy. Symptoms can last up to 15 years after resection. Currently, there is no standard treatment for LARS and management is symptom-based and reactive, rather than proactive. A recent focus group conducted at our institution among LARS patients and caregivers showed that people living with LARS experience anxiety and isolation due to their symptoms.

Peer support could be an important psychosocial intervention for people living with LARS, helping them normalize and validate their experience. Peer support refers to a supportive relationship between individuals who share common experiences or face similar challenges. This approach has been associated with positive physical and mental health outcomes for several patient populations. Our research group conducted a comprehensive review of online health information for patients with LARS, and demonstrated that existing online resources were generally of poor quality and lacked important content. With this knowledge, we created a LARS educational booklet and developed an online app containing LARS educational material and an interactive forum for online peer support. We are now in an optimal position to rigorously test the potential effects of this initiative on patient-centered outcomes.

This study is a multicenter, randomized, assessor-blind, parallel-groups, pragmatic trial involving patients from 5 large colorectal surgery practices (Jewish General Hospital, McGill University Health Centre-Montreal, QC; Toronto Western Hospital, Mount Sinai Hospital- Toronto, ON; Saint Paul's Hospital-Vancouver, BC). Participants will be randomized into the intervention group, who will have access to the online peer support app, and the control group who will only receive a LARS patient educational booklet. Trained peer support mentors will moderate discussion in the peer support forum, which will also be monitored daily by expert health care professionals. Data regarding patient demographics, disease and treatment characteristics will be obtained via hospital chart review. The primary outcome will be health- related quality of life at 6 months. Secondary outcomes will be patient activation and bowel function. We hypothesize that availability of this app (consisting of LARS information, a closed forum for discussion among peers and trained peer support mentors) improves health-related quality of life when compared to the comparison group.

Given the significant numbers of patients who suffer from LARS symptoms following restorative proctectomy and the potential chronic nature of their symptoms, this RCT has the potential to contribute important knowledge to support patient-centered care of rectal cancer survivors. The technology addressed in this study (a mobile app for information and online peer support) is readily accessible and can be relatively easily implemented across large range of geographic jurisdictions and surgical settings.

Interactive Online Informational and Peer Support App for Patients With Low Anterior Resection Syndrome

Interactive Online Informational and Peer Support App for Patients With Low Anterior Resection Syndrome (LARS): A Multicenter Randomized Controlled Trial

Questionnaire measures baseline quality of life before app use. Maximum score 100 (better function, quality of life). Minimum score 0 (worse function, quality of life).

Questionnaire measures change in quality of life after app use. Maximum score 100 (better function, quality of life). Minimum score 0 (worse function, quality of life).

Questionnaire measures patient activation before app use. Maximum score 52 (higher patient activation), Minimum score 13 (lower patient activation).

Questionnaire measures patient activation after app use. Maximum score 52 (higher patient activation), Minimum score 13 (lower patient activation).

Questionnaire measures bowel function before app use. Maximum score 42 (worse bowel function). Minimum score 0 (better bowel function)

Questionnaire measures bowel function after app use. Maximum score 42 (worse bowel function). Minimum score 0 (better bowel function)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
HPV Vaccination Health-promotion Programme on Vaccine Acceptance and Uptake Among Female Adolescents	NCT04438291	HPV Infection Health Behavior Health Attitude	MDL-SHPVP 30-minute educa...	14 Years - 17 Years	Chinese University of Hong Kong
Public Survey on Breath Testing for Health and Disease	NCT06081452	Cancer Disease Health Behavior Health Attitude Health-Related ... Health Knowledg...	Survey	18 Years -	Imperial College London
Interactive Online Informational and Peer Support App for Patients With Low Anterior Resection Syndrome	NCT04469426	Patient Empower... Low Anterior Re... Colo-rectal Can... Peer Group Patient Satisfa... Health Attitude Health Knowledg...	Interactive onl...	18 Years - 100 Years	Jewish General Hospital
Interactive Online Informational and Peer Support App for Patients With Low Anterior Resection Syndrome	NCT04469426	Patient Empower... Low Anterior Re... Colo-rectal Can... Peer Group Patient Satisfa... Health Attitude Health Knowledg...	Interactive onl...	18 Years - 100 Years	Jewish General Hospital

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