Neoplasms

All Conditions

Heart and Blood Diseases

Digestive System Diseases

Carcinoma

Thrombosis

Carcinoma, Hepatocellular

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Patients in this group will receive hepatectomy alone.

Radiotherapy for type I PVTT will be perfomed before hepatectomy. Hepatic resection will be performed in about 4 weeks after radiotherapy.

Hepatectomy alone

Neoadjuvant radiotherapy

Wei-Zhong Tang, MD

The rate of patients with hepatocellular carcinoma (HCC) involving portal vein tumor thrombus (PVTT) is up to 50% in Guangxi province, China. Some of them will receive hepatic resection, especially those with type I or II PVTT. However, 5-years recurrence rate is up to 75% after surgery. Some retrospective studies found postoperative radiotherapy may reduce the rate of recurrence. Moreover, few retrospective studies also found neoadjuvant radiotherapy (PMID: 27317960) may improve overall survival for HCC patients involving type II/III PVTT. However, the safety and efficacy of neoadjuvant raidotherapy for HCC involving type I PVTT is unknown.

Neoadjuvant Radiotherapy for HCC Involving Type I PVTT

Neoadjuvant Radiotherapy for Patients With Hepatocellular Carcinoma Involving Type I Portal Vein Tumor Thrombus

From the date of hepatectomy or neoadjuvant radiotherapy to death or the end of follow-up.

From the date of hepatectomy to HCC recurrence or the end of follow-up.

Guangxi Medical University

Principal Investigator

hepatectomy combined with lymphadenectomy

hepatectomy alone

Yunfei Yuan, MD

The preventive lymphadenectomy is not performed routinely for hepatocellular carcinoma (HCC) patients in clinical practice. While many patients suffered the recurrence without the evidence of portal or hepatic vascular invasion or multiple loci, it lead to reconsider the value of preventive resection of regional lymph node for those patients. Recently, more and more studies had found the incidence of lymph node metastasis was higher in autopsy specimen than those in operable patients.

This project is a prospective randomized controlled trial, planning to compare hepatectomy with hepatectomy combined lymphadenectomy regarding of the safety and efficacy in HCC patients, to reach a further understanding of the role of lymphadenectomy.

Hepatectomy Versus Hepatectomy With Lymphadenectomy in Hepatocellular Carcinoma

Hepatectomy Versus Hepatectomy With Lymphadenectomy in Hepatocellular Carcinoma ----A Prospective Randomized Controlled Clinical Trail

The recurrence-free survival time was defined as the time from the date of resection or ablation to the time of recurrence, metastasis or last follow-up.

Sun Yat-sen University

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Neoadjuvant Radiotherapy for HCC Involving Type I PVTT	NCT04025437	Hepatocellular ...	Hepatectomy alo... Neoadjuvant rad...	18 Years - 75 Years	Guangxi Medical University
Hepatectomy Versus Hepatectomy With Lymphadenectomy in Hepatocellular Carcinoma	NCT02031952	Hepatocellular ...	hepatectomy com... hepatectomy alo...	18 Years - 65 Years	Sun Yat-sen University

Spots Global Cancer Trial Database for hepatectomy alone