Neoplasms

Skin and Connective Tissue Diseases

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Breast Neoplasms

Breast Diseases

Skin Diseases

High-Intensity Focused Ultrasound (HIFU) in the Treatment of Early Breast Cancer prior to surgical resection

Breast cancer will be ablated using high intensity frequency ultrasound prior to breast surgery

High Intensity Focused Ultrasound (HIFU) to the Breast Cancer

Gurdeep S Mannu, MRCSEd DPhil

High Intensity Focused Ultrasound (HIFU) is a new method of treating solid tumours by thermally ablating them. It has been used in a number of different types of cancers but there is little information on its use in invasive breast cancer (IBC). The investigators aim to assess the efficacy and safety of HIFU in the treatment of IBC.

In this study, fifteen otherwise healthy women diagnosed with small, early stage IBC will be treated with HIFU prior to conventional surgical treatment. The effects of HIFU on the resected tumour will be analysed pathologically and correlated with radiological findings. Immune response and participant experience will also be evaluated

High Intensity Focused Ultrasound (HIFU) treatment to breast cancer

The HIFUB Study (HIFU in Breast Cancer)

Study of High Intensity Focused Ultrasound (HIFU) in the Treatment of Early Breast Cancer

Volume of tumour ablation on histological examination of the surgically excised specimen expressed as a percentage of pretreatment tumour volume on MRI scan.

Volume of tumour ablation on histological examination of the surgically excised specimen and volume of tumour ablation on post-treatment MRI expressed as a percentages of pretreatment tumour volume on MRI scan.

Using the Common Toxicity Criteria for Adverse Events (CTCAC) Grading Guideline (which scores any occurring adverse events with grades between 1 to 5, where higher grades indicate worse outcomes)

Using 1 to 1 qualitative interviews with participants.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The HIFUB Study (HIFU in Breast Cancer)	NCT05350059	Breast Cancer	High Intensity ...	18 Years -	University of Oxford
The HIFUB Study (HIFU in Breast Cancer)	NCT05350059	Breast Cancer	High Intensity ...	18 Years -	University of Oxford

Spots Global Cancer Trial Database for high intensity focused ultrasound (hifu) to the breast cancer