Patients deemed to be at intermediate to high risk for postoperative cardiovascular events by clinical criteria will be the subject of this study. Cardiac risk will be determined according to the Revised Cardiac Risk Index (RCRI). RH-PAT testing and BNP evaluation will take place within 30 days before surgery and may occur on separate days. The blood may be drawn on the day of the RH-PAT testing or at a time of routine blood drawing within the 30 day period. After surgery the patient will be monitored and examined in the PACU for evidence of cardiac events.

After obtaining informed consent, eligible patients will undergo endothelial function testing using the Endo-PAT 2000 (Itamar Medical) device. This PAT device applied to the finger tip will be used to measure change in blood flow in one arm at rest and after a 5 minute occlusion of the brachial artery with a blood pressure cuff. The other arm will serve as the patient's own control. After the cuff is deflated, blood flow normally increases in the arm for a period of time (flow mediated dilatation). In patients with abnormal endothelial function, this increase in blood flow is damped. The ratio of flow in the ischemic finger to the nonischemic finger (RH-PAT) will then be correlated with postoperative cardiac events.

endothelial function testing

Michael Baum, MD

The purpose of this study is to look at a new method for finding out if patients have a risk of heart complications from surgery. At the present, to find out if patients have a risk of heart complications from surgery, look at whether the patient has heart disease, diabetes, kidney problems, and stroke. The investigators hope that this study will confirm a new, safe test to help us predict the risk of surgery.

Patients Undergoing Major Cancer Surgery: Incidence and Predictive Value for Postoperative Cardiac Events

Endothelial Dysfunction in Patients Undergoing Major Cancer Surgery: Incidence and Predictive Value for Postoperative Cardiac Events

Identifies patients at high risk of cardiovascular complications after major thoracic or abdominal cancer surgery.

proposed by the American Heart Association/American College of Cardiology.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Patients Undergoing Major Cancer Surgery: Incidence and Predictive Value for Postoperative Cardiac Events	NCT01262222	High Risk for P...	endothelial fun...	50 Years -	Memorial Sloan Kettering Cancer Center
Patients Undergoing Major Cancer Surgery: Incidence and Predictive Value for Postoperative Cardiac Events	NCT01262222	High Risk for P...	endothelial fun...	50 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for high risk for postoperative cardiovascular events