Neoplasms

Digestive System Diseases

All Conditions

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Hematinics

All Drugs and Chemicals

Liver Extracts

This single Cohort/Group will include all consecutive patients that received pre-operative Magnetic Resonance Imaging (MRI) and underwent resection for primary liver tumors.

Non-invasive Magnetic Resonance Imaging (MRI)

Liver resection

Histopathology diagnosis by expert pathologist.

Histopathology diagnosis of resected liver specimen

Stefan Breitenstein, MD

The purpose of this multicenter study is to evaluate the agreement among expert radiologists in interpreting magnetic resonance images (MRI) assessing common primary liver tumours in non-cirrhotic patients.

Magnetic Resonance Imaging (MRI) is currently the method of choice for non-invasive diagnosis of primary liver tumors. However, differentiation of hepatocellular carcinoma (HCC) from adenoma and focal nodular hyperplasia (FNH) remains challenging, particularly in non-cirrhotic patients.

Agreement Among Expert Radiologists in Diagnosing Primary Liver Tumors by Magnetic Resonance Imaging (MRI)

Agreement Among Expert Radiologists in Diagnosing Primary Liver Tumors by Magnetic Resonance Imaging (MRI) in Non-Cirrhotic Patients - A Double Blind International Multicenter Study

Inter-observer agreement for categorical data will by assessed by the Fliess' kappa (good agreement \>0.7).

The actual diagnosis is defined as the histopathology diagnosis of the resected liver specimen, the current gold standard technique. Such agreement will be assessed by Cohen's Kappa (good agreement \>0.7).

Radiologist' certainty of diagnosis (CoD) will be assessed by a Visual Analogue Scale (VAS 1-10). Potential differences in CoD will be identified by non-parametric multiple comparisons.

Intra-class correlation coefficient is a descriptive statistic that can be used when quantitative measurements are made on units that are organized into groups. It describes how strongly units in the same group resemble each other.

Diagnostic efficacy will be assessed by Receiver Operating Characteristic (ROC) Curves.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Agreement Among Expert Radiologists in Diagnosing Primary Liver Tumors by Magnetic Resonance Imaging (MRI)	NCT01234701	Neoplasms	Non-invasive Ma... Liver resection Histopathology ...	18 Years - 90 Years	University of Zurich
Agreement Among Expert Radiologists in Diagnosing Primary Liver Tumors by Magnetic Resonance Imaging (MRI)	NCT01234701	Neoplasms	Non-invasive Ma... Liver resection Histopathology ...	18 Years - 90 Years	University of Zurich
Agreement Among Expert Radiologists in Diagnosing Primary Liver Tumors by Magnetic Resonance Imaging (MRI)	NCT01234701	Neoplasms	Non-invasive Ma... Liver resection Histopathology ...	18 Years - 90 Years	University of Zurich

Spots Global Cancer Trial Database for histopathology diagnosis of resected liver specimen