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A homologous recombination deficiency (HRD) scoring model based on loss of heterozygosity (LOH)

Homologous recombination deficiency model

Lei Li, M.D.

Ming Wu, M.D.

Lei Li, MD

A homologous recombination deficiency (HRD) scoring model based on loss of heterozygosity (LOH) is little explored in epithelial ovarian cancer (EOC) patients. This study would recruit 200 Chinese EOC patients with known BRCA1/2 mutation status and resistance to platinum-based chemotherapy. A LOH-HRD model is to be constructed based on the genetic testing in these patients. The mutated genes, HRD score model and their relationship with the prognosis, would provide a full description of for the Chinese EOC patients, and a potential explanation of platinum-resistance in such population.

Samples from the patients' peripheral blood and tumor tissues.

A Training Set for the HRD Model in EOC

A Training Set for the Homologous Recombination Deficiency Scoring Model With Loss of Heterozygosity Status in Epithelial Ovarian Cancer

The HRD score for individual patient is a scale describing her HRD status. The score model is calculated by the analysis for loss of heterozygosity (LOH), and the minimum value is 0, but the maximun value is not available. Higher scores mean more sensitivity to poly-ADP-ribose polymerase inhibitor

Progression-free survival in recruited patients

Lei Li

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Training Set for the HRD Model in EOC	NCT04651933	Epithelial Ovar... BRCA Mutation Loss of Heteroz... Prognosis Platinum Resist... Homologous Reco...	Homologous reco...	18 Years -	Peking Union Medical College Hospital
A Training Set for the HRD Model in EOC	NCT04651933	Epithelial Ovar... BRCA Mutation Loss of Heteroz... Prognosis Platinum Resist... Homologous Reco...	Homologous reco...	18 Years -	Peking Union Medical College Hospital

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