Infections

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Vaginal Diseases

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Disease Attributes

Genital Diseases

Urogenital Diseases

Cervical Intraepithelial Neoplasia

Leandro A Mena, MD, MPH

The purpose of this study is to determine the rates of sexually transmitted infections (STI) among a group of African American women who have sex with women (AA WSW). The first study hypothesis is that AA WSW are at risk for acquiring and transmitting STI, including the human immunodeficiency virus (HIV). The second study hypothesis is that AA WSW participate in multiple high-risk sexual activities that may facilitate transmission of STIs, including HIV.

Historically, women who have sex with women (WSW) have been thought to be at low risk for acquiring sexually transmitted infections (STI), presumably due to the absence of genital mucosal contact present during vaginal-penile sex or due to the assumption that the vaginal mucosa experiences a lesser degree of trauma during female sex than during heterosexual sex. This assumption has been challenged and debated over the past two decades. In addition, the sexual health risks of WSW are only beginning to be understood.

To date the majority of research regarding STI in women has occurred in heterosexuals. National and local surveillance data that estimate the risk for STI transmission between WSW are limited, especially among African Americans. This is a group of women that may exhibit distinctive behavioral characteristics that may put them at higher risk for sexually transmitted infections STI and HIV than their Caucasian counterparts. This group of women has traditionally been reluctant to discuss their sexual orientation with physicians for fear of being stigmatized. The burden of STIs, including HIV, experienced by this group of women is largely unknown.

Endocervical and vaginal secretion specimens are being retained for future research studies in this field of sexually transmitted diseases.

Sexually Transmitted Infections Among African American Women Who Have Sex With Women

Prevalence Rates of Sexually Transmitted Infections and Sexual Risk Behaviors Among African American Women Who Have Sex With Women

Data will only be shared with investigators

Mississippi State Department of Health

University of Alabama at Birmingham

University of Mississippi Medical Center

Associate Professor of Medicine

Substance Related Disorders

Behaviors and Mental Disorders

Neoplasms

Alcoholism

Sarcoma

Sarcoma, Kaposi

Disease Susceptibility

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Alcohol-Related Disorders

Substance-Related Disorders

Chemically-Induced Disorders

Mental Disorders

Psychotic Disorders

Herpesviridae Infections

DNA Virus Infections

Neoplasms, Vascular Tissue

Soft Tissue Sarcoma

Kaposi Sarcoma

Anti-Infective Agents

Central Nervous System Depressants

All Drugs and Chemicals

Ethanol

We propose to test, by DNA linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of Kaposi's sarcoma and other outcomes of HIV infection in male homosexuals is affected by host susceptibility genes, circulating sex hormone levels, or HLA haplotype; and 3) that alcoholism and other psychobehavioral conditions are associated with homosexuality on a genetic basis and/or influenced by candidate behavioral loci. The subjects for these studies will be self-identified male and female homosexual probands and their relatives from families in which there are at least two individuals with homosexual orientation. All subjects will be adults, and will be referred through NIH physicians, private practitioners, and gay and lesbian organizations. Subjects will undergo a sexual orientation and behaviors interview, a psychiatric interview, and phlebotomy for HIV testing, HLA determination, endocrine measurements, and preparation of DNA from cultured lymphocytes. The DNA samples will be analyzed for a series of genetic markers that span the human genome and for candidate loci chosen for function.

Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility Antigens

National Cancer Institute (NCI)

Study title	NCT ID	Conditions	Eligibility	Organization
Sexually Transmitted Infections Among African American Women Who Have Sex With Women	NCT01043081	Sexually Transm... HIV Infections	18 Years -	University of Mississippi Medical Center
Sexually Transmitted Infections Among African American Women Who Have Sex With Women	NCT01043081	Sexually Transm... HIV Infections	18 Years -	University of Mississippi Medical Center
Sexually Transmitted Infections Among African American Women Who Have Sex With Women	NCT01043081	Sexually Transm... HIV Infections	18 Years -	University of Mississippi Medical Center
Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility Antigens	NCT00001294	Alcoholism HIV Infection Homosexuality Kaposi's Sarcom...	-	National Institutes of Health Clinical Center (CC)
Sexually Transmitted Infections Among African American Women Who Have Sex With Women	NCT01043081	Sexually Transm... HIV Infections	18 Years -	University of Mississippi Medical Center

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